Cytotoxic stress caused by azalamellarin D (AzaD) interferes with cellular protein translation by targeting the nutrient-sensing kinase mTOR.

Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B6C3F1 mice, Toxicology Reports. Tangjarukij, C., Settachan, D., Zelikoff, J.T., Navasumrit, P., Ruchirawat, M. 8 (2021) 1607–1615.

A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress Fedeles BI, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade DC, Westergerling P, Staudner T, Campolo J, Liu SS, Dong K, Cai Y, Rehman M, Gallagher A-R, Ruchirawat S, Croy RG, Essigmann JM, Fedeles SV, Somlo S Proc Natl Acad Sci U S A. 2024;121:e2317344121.