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Laboratory of Biochemistry

Laboratory of Biochemistry

Laboratory of Biochemistry

      Although the human genome sequence provides a molecular blueprint of an organism, the information encoded in DNA is not enough to understand how living organisms function, since it has to be expressed through the synthesis of proteins. Proteins may be further modified, such as by glycosylation or phosphorylation, and must fold into a complex three-dimensional structure, which makes them highly specific and efficient as biological catalysts. We have been interested in protein structure and function for many years, and have now focused our interests on the abnormalities in the amount and/or function of proteins, which can give rise to diseases, such as cancer and genetic diseases. Understanding such defects can provide important leads to devising cures for diseases and improve the quality of life of the Thai people, which is the goal of the Chulabhorn Research Institute.

Director: Professor Emeritus Dr. M.R. Jisnuson Svasti

        Proteins express the genetic potential of an organism and can perform numerous functions, such as enzymatic catalysis of reactions, acting as structural frameworks in the body, and transport of substances between organs. Because of their vital importance in the function of the body, abnormalities in the amino acid sequence, chemical modification, or expression in tissues, can give rise to disease. Mutation is the genetic alterations at DNA level and leads to produce proteins with abnormalities in their structures and functions, causing genetic diseases and cancer, that are diseases with difficulty intervention and being a public health problem in Thailand.

        We have been interested in the changes in proteins giving rise to human diseases for many years, most notably in genetic diseases and cancer. This research has led to several awards, such as the Outstanding Scientist Award from the Foundation for the Promotion of Science and Technology under the Patronage of His Majesty the King, the Senior Research Scholar Award from the Thailand Research Fund, and the Outstanding Researcher Award in Chemistry and Pharmacy from the National Research Council of Thailand.

Our research interests at the Laboratory of Biochemistry are to study diseases arising from abnormalities of proteins, both in terms of changes in their amounts or modifications of their structure which affect their ability to perform their function. Major research areas include:

1. Cancer Biomarkers
2. Anti-Cancer Agents and Tumor Microenvironment
3. Genetic diseases
4. Action of environmental contaminants on human health

This work has been published as numerous articles in international journals and researchers in the laboratory have received several awards, such as the Outstanding Scientist of Thailand Award and the Outstanding Researcher Award.

See All

Research Activities

Novel Therapeutic Strategies
Tumor microenvironment
Cancer biology: metastasis, blood vessel formation and drug resistance
Post-translational Modifications in Cancer
Cancer Proteomics and Biomarker Exploration
Genetic Diseases found in Thailand


Laboratory of Biochemistry

Chulabhorn Research Institute

7th Floor, Biomedical Science Building

54 Kamphaeng Phet 6 Rd., Talat Bang Khen, Lak Si, Bangkok 10210 THAILAND


+66 2553 8679


+66 2553 8560

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