Name: Dr. Pattama Singhirunnusorn Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662–5538555 ext. 3135 (office), +6687–5915431 (mobile) Fax:+662–5538572 Positions:Research Scientist, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute E–mail:[email protected] Website:– Research Interests Signal transduction Cell and Molecular Biology Education and Degrees: B.Sc. (Chemistry), Suan Dusit Rajabhat University, Bangkok, Thailand, 1994–1997 M.Sc. (Pharmaceutical Chemistry), Mahidol University, Bangkok, Thailand, 1999–2002 Ph.D. (Pharmaceutical Science), University of Toyama, Toyama, Japan, 2002–2005 Academic Positions Researcher, Department of Pharmacognosy, Faculty of pharmacy, Mahidol University, Thailand, 1998 Postdoctoral Fellow, Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Japan, 2006–2008 Researcher, Chemical Carcinogenesis laboratory, Chulabhorn Research Institute, 2008–present Academic Activities Local Activities Project proposal committee (2015–2016), Thesis defend committee (2016–2017), Anti–Aging and Regenerative Medicine Faculty, Dhurakij Pundit University Fellowships Postdoctoral Fellow, Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Japan, 2006–2008 International Awards & Honours Toyama New Industry Organization Grants, Japan, 2006–2007 Monbukagakusho Scholarship, Japan, 2002–2005 Local Awards & Honours Poster award at The 10th National Cancer Conference, Bangkok, Thailand, 2009 ORCID iD: https://orcid.org/0000–0002–8085–5417 Publications A. Research Articles in International Journals Singhirunnusorn, P., Moolmuang, B., Lirdprapamongkol, K., & Ruchirawat, M. (2018). Arsenite exposure potentiates apoptosis–inducing effects of tumor necrosis...

Name: Dr. M.L. Siritida Rabibhadana Office address: Research Laboratory of Chemical Carcinogenesis,Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 ext 3130 Position: Research Scientist E-mail:[email protected] Research Interests:Cell and Molecular Biology Education and Degrees: B. Sc.(Biotechnology)Mahidol University, 1983-1987 M. Sc. (Microbiology)Mahidol University, 1987-1991 Ph. D. (Microbiology)Mahidol University, 1991-1996 Awards Award of Highest Grade Point Average from Dr. Tab Foundation, 1987 Scholarship from the National Center of Genetic Engineering and Biotechnology, 1990 Scholarship from the National Science and Technology Agency, 1991-1996 Work Activities August 1989-October 1989 Molecular Biology Training at University of Maryland, Baltimore County, USA October 1989-April 1990 Molecular Training at Oregon State University, USA September 1998-March 1999 Molecular Training at International Agency for Research on Cancer (IARC), Lyon, France June 28, 2003-July 26, 2003 Microarray Technology Training at Massachusetts Institute of Technology (MIT), Cambridge, MA, USA February 23, 2004-March 31, 2004 Microarray Technology Training at Oregon Health Science Technology (OHSU), Portland, OR, USA November 1, 2004 -January 27, 2005 ELISA Technique Training at National Cancer Institute (NCI), Bethesda, MD, USA Publications Schaffer, A. A., Dominguez, D. A., Chapman, L. M., Gertz, E. M., Budhu, A., Forgues, M., . . . Wang, X. W. (2021). Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does...

Name: Dr. Jittiporn Chaisaingmongkol Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 ext. 3136 (office) Fax:+662-5538572 Position: Research Scientist I, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute E-mail:[email protected] Research Interests Cancer biology and molecular biology (Epigenetics and DNA repair) Integrated and functional genomics of human liver cancer (Hepatocellular carcinoma and cholangiocarcinoma) Education and Degrees: 2000 – 2006 Diplom Degree (Bachelor and Master degree) Bayerischen Julius-Maximilians-Universitaet Wuerzburg, Wuerzburg, GERMANY 2006 – 2011 Doctor of Science (DR. RER. NAT.) Ruperto-Carola University of Heidelberg, Heidelberg, GERMANY Fellowships 2011 Postdoctoral Fellow at the German Cancer Research Center, Heidelberg, GERMANY 2013-2016 Visiting fellow at Laboratory of Human Carcinogenesis, National Cancer Institute, National Institute of Health, Bethesda, MD, USA ORCID iD: https://orcid.org/0000-0001-8019-5562 Publications Ma L, Heinrich S, Wang L, Keggenhoff FL, Khatib S, Forgues M, et al. Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer. Nat Commun. 2022;13(1):7533. Khatib SA, Ma L, Dang H, Forgues M, Chung JY, Ylaya K, et al. Single-cell biology uncovers apoptotic cell death and its spatial organization as a potential modifier of tumor diversity in HCC. Hepatology. 2022;76(3):599-611. Schaffer AA, Dominguez DA, Chapman LM, Gertz EM, Budhu A, Forgues M, et al. Integration of adeno-associated virus (AAV)...

Name: Dr. Benchamart Khumkrong Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662–5538555 ext. 3136 (office), +6680–9001736 (mobile) Fax:+662–553–8572 Positions:Research Scientist I, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute E–mail:[email protected] Website: Research Interests Cancer biology Cell and molecular biology Cholangiocarcinoma Education and Degrees: B.Sc. Biology, Khon Kaen University, Thailand, 2001 M.Sc. Molecular Genetics and Genetic Engineering, Mahidol University, Thailand, 2004 Ph.D. Cancer Biology Program, Wayne State University, USA, 2010 Academic Positions Research Assistant, Genomic Lab, Mahidol University, 2004–2005 Research Associate, Tainsky Lab, Wayne State University, 2010 Researcher Scientist I, Chemical Carcinogenesis Laboratory, Chulabhorn Research Institute, 2010–present Local Awards & Honours The Development and Promotion of Science and Technology Talent Project Scholarship granted by the Ministry of Science and Technology, Thailand, 1998–2004 The Thai Government Science and Technology Scholarship for Doctoral study granted by the Office of the Civil Service Commission, Thailand, 2005–2010 A New Researcher Scholarship of Coordinating Center for Thai Government Science and Technology Scholarship Students (CSTS), 2011–2012 ORCID iD : https://orcid.org/0000–0003–2008–4021 Publications Research Articles in International Journals Moolmuang, B., & Ruchirawat, M. (2021). The antiproliferative effects of ataxia–telangiectasia mutated and ATM– and Rad3–related inhibitions and their enhancements with the cytotoxicity of DNA damaging agents in cholangiocarcinoma cells. J Pharm Pharmacol, 73(1), 40–51....

Name: Dr. Anyaporn Chailert Office address: Chemical Carcinogenesis Laboratory, Biomedical Building54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 25530 8555 (ext. 8253) E-mail: Research Experience (Specialties): Cell and Molecular Biology Education 2006-2007 B.A. (Biology), Kasetsart University 2007 B.A. (Major: Biological Science Minor: Chemistry), Mt Holyoke College, MA, USA. 2011 Ph.D. (Biochemistry), University of Bristol, UK. Awards 2004 Summa Cum Laude (graduated with highest honor), Worcester Academy 2005 Margaret Andrew Winter 35 Endowed scholarship for summer research, Mt Holyoke College. 2006 Independent Study Grant, Mt Holyoke College 2009 Conference Grant, University of Bristol 2002 – 2011 Development and Promotion of Science and Technology (DPST) scholarship, The Royal Thai Government. 2012 – present Chulabhorn Research Institute grant. Work Activities 2006–2007 Lab-prep Assistant, Mt Holyoke College 2007–2010 Laboratory Demonstrator/mentor. University of Bristol 2011- 2012 Postdoctoral Fellow, Collaboration project between University of Birmingham, University of Bristol, and Bristol Royal Infirmary Hospital 2012-present Visiting Lecturer, Biology, Gifted Program: Benjamarachanusorn School 2012-present Visiting Lecturer, Biology, English Program: Yothinburana School 2013 Visiting Lecturer, Cell Biology of Aging in Anti-Aging and Regenerative Medicine Program, Dhurakit Pundit University. 2011-present Researcher, Chemical Carcinogenesis laboratory,Chulabhorn Research Institute Publications Philip Kitchen, Danielle Clark, Ka Ying Lee,Jomnarong Lertsuwan, Anyaporn Sawasdichai, Sebastien Olteam4, Simon Afford, Jutamaad Satayavivad,Kevin Gaston and Padma-Sheela Jayaraman. Poster Presentation: PRH as a potential driver...

Prof. Dr. Her Royal Highness Princess Chulabhorn, the President of the Chulabhorn Research Institute, Thailand spent a 4-day visit to Brunei Darussalam during October 14th-18th, 2013 to deliver a lecture at the Universiti Brunei Darussalam on Risk Assessment and Management of Chemicals and was received by His Majesty the Sultan and Yang Di-Pertuan of Brunei Darussalam. Prof. Dr. Her Royal Highness Chulabhorn was also graciously received by Her Majesty Raja Isteri Pengiran Anak Hajah Saleha The invitation from Universiti Brunei Darussalam to Prof. Dr. Her Royal Highness Princess Chulabhorn to participate in this event underscored the close and cordial relations between Thailand and Brunei Darussalam, reflecting the long established bond of friendship between the two Royal Families and the two countries. The four days event was held from October 14th-18th, 2013 with opening lecture by Professor Dr. Her Royal Highness Princess Chulabhorn Mahidol, the President of Chulabhorn Research Institute Thailand. The course focuses on the adverse health effects of human exposure to chemical hazards, such as industrial waste, and other problems faced by developing countries. HRH said she founded the Chulabhorn Research Institute to improve the lives of people in the region through scientific research. It is a significant platform for training and building national capabilities as well as capacities of expertise among professionals in chemical safety, using a self-guided...

ศาสตราจารย์ ดร. สมเด็จพระเจ้าลูกเธอ เจ้าฟ้าจุฬาภรณวลัยลักษณ์ อัครราชกุมารี จะทรงเข้าร่วมประชุมวิชาการด้านอนามัยสิ่งแวดล้อมของกลุ่มประเทศภาคพื้นแปซิฟิก ครั้งที่ ๑๕ ในหัวข้อ “การรับสัมผัสสารจากสิ่งแวดล้อมในประชากรพื้นเมือง” และการประชุมเพื่อจัดตั้งเครือข่ายความร่วมมือด้านสุขอนามัยสิ่งแวดล้อมของเด็กและเยาวชน ณ East – West Center นครโฮโนลูลู มลรัฐฮาวาย สหรัฐอเมริกา ระหว่างวันที่ 20-30 กันยายน 2556 ในการนี้ จะทรงเข้าร่วมพิธีเปิดการประชุม และจะทรงบรรยายในหัวข้อ ““ผลกระทบต่อสุขภาพในอนาคตจากการได้รับสัมผัสมลพิษในสิ่งแวดล้อมในวัยเด็ก” นอกจากนี้ จะทรงเป็นประธานร่วมในการประชุมภาคบรรยายพิเศษกับผู้อำนวยการด้านสาธารณสุขและสิ่งแวดล้อมขององค์การอนามัยโลกในหัวข้อ “โครงการขยะอิเล็กทรอนิกส์ขององค์การอนามัยโลก” และทรงได้รับเชิญให้เข้าร่วมการประชุมเพื่อจัดตั้งเครือข่ายความร่วมมือในด้านสุขอนามัยสิ่งแวดล้อมของเด็กและเยาวชน ซึ่งเป็นความร่วมมือระหว่าง The Pacific Basin Consortium for Environment and Health (PBC) และ WHO Department of Public Health and Environment และ National Institute of Environmental Health Sciences อีกด้วย ฝ่ายบริหารและประชาสัมพันธ์ 23 กันยายน 2556

Her Majesty Queen Sirikit’s Birthday is on August 12. The day is also celebrated as Mother’s Day in Thailand. The Queen is much respected by Thai people. Her maternal care for the people and her devotion to improve their welfare and well-being have earned her the honor of being “Mother of the Land”. Every year on August 12, ceremonies to honor Her Majesty the Queen are held nationwide by government offices and private establishments alike. Honoring the Queen, motherhood and maternal bonds, is an essential part of these public events and activities, to show gratitude for her benevolence and in recognition of the good work she has been doing for her people. Throughout the long years as Queen Consort of His Majesty King Bhumibol, the longest reigning monarch in the world, the Queen has been a working royal sharing the King’s burdens and responsibilities by assisting him tackle the country’s complex problems. Her efforts and achievements, mainly humanitarian, focus on helping the poor majority in rural areas, on natural and environmental conservation, wildlife preservation, and in particular on special home industries as vital supplements to low rural incomes benefiting rural un-employment especially among the women. Very remarkable are Her Majesty’s patronage and development projects in the provinces that have successfully revived and perpetuated the very rich legacy of folk arts...

The Office of Research, Chulabhorn Research Institute, undertook a project for the improvement of the facility and animal care and use program of the Laboratory Animal Unit (LAU) under the Office of Research, by applying for the accreditation of the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International) in Frederick, Maryland, USA. On October 15, 2008, an institutional committee, accordingly, was appointed to be responsible for the management of high quality facilities and programs for the care and use of laboratory animals in compliance with the international standards set forth by AAALAC International. The AAALAC accreditation program evaluates organizations that use animals in research, teaching or testing. Those that meet or excel AAALAC standards are awarded accreditation. The accreditation helps to raise the global benchmark for animal well-being in science. It also represents quality of good science as it promotes scientific validity. Striving to achieve the highest international standards of quality animal care and use, the Chulabhorn Research Institute’s IACUC had been engaging in overseeing the management for the care and use of the laboratory animals (i.e. rodents : rats and mice), and in proceeding with the work related to the accreditation requirements. These included, for example, written documents, the appointment of the Occupational Health and Safety Committee, the improvements of the animal facility building interior,...

The new study, in establishing the potential harmful effects of prenatal exposures, provides a possible method of screening populations to detect signs of arsenic contamination. Moreover, it is the first study to provide evidence of genome-wide changes resulting from prenatal exposure from any environmental contaminant. In a collaborative study, researchers at the Chulabhorn Research Institute (CRI) in Thailand and of the Massachusetts Institute of Technology (MIT) in the United States have found that the children of mothers exposed to water supplies contaminated with arsenic during their pregnancies showed gene expression changes that could lead to cancer and other diseases later in life, even if the children themselves were never directly exposed to arsenic. The new study, in establishing the potential harmful effects of prenatal exposures, provides a possible method of screening populations to detect signs of arsenic contamination. Moreover, it is the first study to provide evidence of genome-wide changes resulting from prenatal exposure from any environmental contaminant. Arsenic contamination is a health concern worldwide with millions exposed to levels that exceed the World Health Organization (WHO) safety standard of 10 parts per billion (ppb). The element was classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC) and has been implicated in such diseases as vascular disorders and diabetes. The CRI research team included...