Assoc. Dr. Oranart Matangkasombut

26 Mar 2015

Name: Assoc. Dr. Oranart Matangkasombut

Office address: Laboratory of Biotechnology
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 25530 8555 (ext. 3251)
E-mail[email protected]

Research Scientist

Research Experience (Specialties)

  • Molecular biology


  • 1988-1994 DDS, Chulalongkorn University
  • 1996-2002 PhD (Biological Sciences in Dental Medicine), Harvard University
  • 2002-2004 Postdoctoral fellowship (with Prof. Gerald R.Fink), Whitehead Institute for Biomedical Research, MA, USA


  • 1995 Anandamahidol scholarship in Dentistry
  • 2002 Harvard School of Dental Medicine Dean’s scholar award


– Cefai D., Schneider H., Matangkasombut O., Kang H., Brody J., Rudd C.E. (1998) CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. J Immunol,160(5):2223-30

Matangkasombut O., Buratowski R.M., Swilling N., Buratowski S. (2000) Bromodomain factor1 corresponds to a missing piece of yeast TFIID. Genes.Dev. 14(8):951-6

Matangkasombut O., and Buratowski S. (2003) Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation. Mol. Cell 11(2):353-63

Matangkasombut O., Auty R., Buratowski S. (2004) Structure and function of the TFIID complex. Adv Protein Chem. 67:67-92.

Matangkasombut O. (2006) Oral Candidiasis Part I : Clinical Manifestations and Etiology. J Dent Assoc Thai. 56 (1): 52-63

Matangkasombut O. (2006) Oral Candidiasis Part II : Current therapeutic guidelines. J Dent Assoc Thai. 56 (1): 64-75

Matangkasombut O., Siraprapa J., and Wongpraparat I. (2006) The development of a PCR-based assay for the detection and identification of Candida in oral samples. CU Dent J. 29(2): 83-94

Cowen L.E., Carpenter A.E., Matangkasombut O., Fink G.R., Lindquist S. (2006) Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell. 5(12):2184-8

– Pitiphat W, Matangkasombut O, Merchant A. (2007) Re: effect of periodontal treatment on serum C-reactive protein levels: a systematic review and meta-analysis. Ioannidou E, Malekzadeh T, Dongari-Bagtzoglou A. (2006;77:1635-1642). J Periodontol. 78(7):1184-5; author reply 1186-7.

Pornthanakasem W, Kongruttanachok N, Phuangphairoj C, Suyarnsestakorn C, Sanghangthum T, Oonsiri S, Ponyeam W, Thanasupawat T, Matangkasombut O, Mutirangura A. (2008) LINE-1 methylation status of endogenous DNA double-strand breaks. Nucleic Acids Res. 36(11):3667-75, doi:10.1093/nar/gkn261 published online: May 12. [Epub ahead of print]

– Samaksamarn T,  Sutthiboonyapan C, Pipattanagovit P, and Matangkasombut O. (2008) Antibacterial effect on Enterococcus faecalis of erbium, chromium: yttrium-scandium-gallium-garnet laser irradiation compared to two irrigating solutions in root canals of extracted human teeth. J Dent CU. 31(2): 125-34

Subbalekha K, Pimkhaokham A, Pavasant P, Chindavijak S, Phokaew C, Shuangshoti S, Matangkasombut O, Mutirangura A. (2009) Detection of LINE-1s hypomethylation in oral rinses of oral squamous cell carcinoma patients. Oral Oncol. Feb;45(2):184-91. Article first published online: 18 Aug 2008.

Matangkasombut O, Wattanawaraporn R, Tsuruda K, Ohara M, Sugai M, and Mongkolsuk S. (2010) Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest and caspase-independent death in a Saccharomyces cerevisiae model. Infect. Immun. 78(2), 783-792., doi:10.1128/IAI.00857-09, Article first published online: 7 Dec 2009

– Santiwongkarn P, Kachonboon S, Thanyasrisung P and Matangkasombut O. (2012) Prevalence of oral Candida carriage in Thai adolescents. J Investig Clin Dent. Feb;3(1):51-5.doi: 10.1111/j.2041-1626.2011.0089.x Article first published online: 7 Aug 2011

– KantaputraPN, Matangkasombut O, and Sripathomsawat W. (2012) Split Hand-Split Foot-Ectodermal Dysplasia and Amelogenesis Imperfecta with a TP63 Mutation.
Am J Med Genet A. Jan;158A(1):188-92.doi: 10.1002/ajmg.a.34356. Article first published online: 7 Nov 2011

– Thongsroy J, Matangkasombut O, Thongnak A, Rattanatanyong P, Jirawatnotai S, and Mutirangura A. (2013) Replication-Independent Endogenous DNA Double-Strand Breaks in Saccharomyces cerevisiae Model. PLoS One. Aug 19;8(8):e72706. doi: 10.1371/journal.pone.0072706.

– Thanyasrisung P, Kesakomol P, Pipattanagovit P, Youngnak-Piboonratanakit P, Pitiphat W, and Matangkasombut O. (2014) Oral Candida carriage and immune status in Thai HIV-infected individuals. J Med Microbiol. May;63(Pt 5):753-9 doi: 10.1099/jmm.0.069773-0. Article first published online: 3 Mar 2014

– Panjinda R, Matangkasombut O, Ampornaramveth R, Subbalekha K (2014) Antibacterial efficacy of alcohol on dental anesthetic cartridges. CU Dent J. 37(1),59-68

– Ittatirut S, Matangkasombut O, Thanyasrisung P. (2014) In-office bleaching gel with 35% hydrogen peroxide enhanced biofilm formation of early colonizing streptococci on human enamel. J Dent. Aug 15. pii: S0300-5712(14)00237-1. doi: 10.1016/j.jdent.2014.08.003. [Epub ahead of print]


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