The 9th Princess Chulabhorn International Science Congress

Arsenic is an environmental pollutant that is classified as a human carcinogen by the International Agency for Research on Cancer (IARC). It is found naturally in the environment and is also used as a therapeutic agent in pigs and chickens, as well as a pesticide. In Thailand, arsenic contamination in the environment is mainly because of tin mining, leading to contamination of food and drinking water. In animal experiments, arsenic has been shown to cross the placenta to the developing embryo and lead to cancer later in life (i.e., adulthood). The Chulabhorn Research Institute has conducted research on the impacts of exposure to arsenic in pregnant mothers on gene expression in infants. Tissue samples were collected from mothers and newborns from Ronpibul district, Nakhon Sri Thammarat province, an area known to be contaminated with arsenic. Results showed that newborns from mothers in the study area had elevated levels of arsenic in their hair and nails, compared to newborns from a control site. This was also the first published study to show differential expression of 11 genes that were identified as promising markers for arsenic exposure. These genes are involved in apoptosis, cell signaling, inflammation and stress responses. Additionally, it was found that levels of DNA methylation in the promoter region of the p53 gene were associated with levels of arsenic...

Name : Dr. Rattana Worayuthakarn (Research Scientist) Office Address : Room : R413 / R403B Laboratory of Medicinal Chemistry 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel : +66 2553 8555 (ext. 3044) Email : [email protected] Research Interests Synthetic methodology Total synthesis of natural products Education 2001 – 2006 Ph.D Organic Chemistry, Mahidol University, Thailand 1998 – 2000 M.Sc. Organic Chemistry, Prince of Songkla University, Hat Yai, Thailand 1994 – 1997 B.Sc. Chemistry, Prince of Songkla University, Hat Yai, Thailand Work Experiences 2006 – 2019 Research Assistant, Chulabhorn Research Institute, Thailand 2019 – present Research Scientist, Chulabhorn Research Institute, Thailand Awards 2001-2003 Scholarship of The institutional strengthening program, Mahidol University 2001-2004 The Postgraduate Education and Research Program in Chemistry (PERCH), Mahidol University 2004-2006 Programme on Research and Development of Synthetic Drugs, Institute of Science and Technology for Research and Development, Mahidol University, Salaya Campus, Nakornpathom, Thailand Publications Selected Publications Worayuthakarn, R.; Suddee, N.; Nealmongkol, P.; Ruchirawat, S.; Thasana, N. Copper-mediated C-O/C-N Bond Formation: A Facile Synthesis of 3-Amidocoumarin, 3-Amidoazacoumarin, and N-Aeroylindole Derivatives. Synlett 2022, 33, 1431–1437. Worayuthakarn, R.; Deesiri, S.; Chainok, K.; Wannarit, N.; Ruchirawat, S.; Thasana, N. Highly Regioselective Tandem Reaction of Ene-Yne-Oxazolones Induced by H-Phosphonates: Construction of Phosphinylindane Derivatives. J. Org. Chem. 2021, 86, 9360–9383. Pramthaisong, C.; Worayuthakarn R.; Pharikronburee, V.; Duangthongyou, T.;...