Previous Next All personnel working with animals are trained prior to commencing work 1. Ethics and welfare in animal experimentation and protocol writing for investigators who will prepare the animal use protocol 2. Animal training procedures as requested depending on the specific animal protocol 3. Occupational health and safety Routine prophylaxis and screening Personnel Protective Equipment General Biosafety and Blood-borne Pathogens Chemical safety General Laboratory Safety and Lab Waste Management Safety shower and eyewash training Fire Prevention-Emergency Preparedness and Rescue Plan 4. LAC-SOP training related to individual task
Previous Next Animal Environment The temperature is regulated at 22±1oC, with a relative humidity (RH) of 55±10% and air exchange rate is set not to fall below 15 air changes/hr. throughout each 24-hour period. The temperature RH and air exchange rate in each room are monitored and recorded in real time by a computer monitoring system. Sound level and light intensity is not exceed 85 dB, 325 lux respectively in animal housing area. Ammonia levels should not exceed 25 ppm in any type of animal facility. Animal Supplies Supplies must have certification as the standard values. Each lot of supplies are sampled and tested for microbial contamination, heavy metal or others that researcher or veterinarian requested by the outsource certified laboratory. Micro- and Macro-Environments Cages and lids, filtered top cages, ventilated cages, water bottles, rack/shelves, laminar flow racks, safety cabinets and other animal equipment are routine sanitized in scheduled frequency. The effectiveness of sanitization procedures is monitored (e.g., water temperature monitoring, sterility test, microbiological monitoring, visual inspection and other indicators) Animal rooms sanitation is monitored using air sampler routinely
Previous Next Animal research conducted at CRI includes the search for new anti-malarial drugs, and factors affecting susceptibility to malarial infection; studies on animal models of various types of cancers; toxicity of metals, pesticides and air pollutants; acute and chronic toxicity of chemicals found in natural sources; and the health effects of climate change. The major users of the animal facility are researchers from laboratories of Environmental Toxicology, Pharmacology, Immunology, as well as Translational Research Center.
Previous Next 2 Full-time veterinarians (1 Attending Veterinarian and 1 Clinical Veterinarian) has direct responsibility for ensuring adequate veterinary care and is also responsible for ensuring adequate resources to care for animals; proper methods to prevent diseases; communication regarding animal health issues; advising technical and professional staff on proper animal care and use; ensuring proper care and storage of equipment and supplies; and all other aspects of the veterinary care program. Also, the duties engage in protocol support discussion with investigators and coordinates with the veterinary technician. The veterinary technician and animal caretakers are available during the workday from 9 am to 5 pm. They observe the animals during feeding and/or treatment/protocol-related activities. The animals are observed at least once daily also weekend and holiday. After hours observation or treatment is done on an “as needed” basis, when there is a scheduled protocol or emergency medical attention is required.