Dr. Rattana Worayuthakarn

26 Jan 2023

Name : Dr. Rattana Worayuthakarn (Research Scientist)
Office Address : Room : R413 / R403B
Laboratory of Medicinal Chemistry
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3044)
Email : [email protected]

Research Interests
Synthetic methodology
Total synthesis of natural products

2001 – 2006 Ph.D Organic Chemistry, Mahidol University, Thailand
1998 – 2000 M.Sc. Organic Chemistry, Prince of Songkla University, Hat Yai, Thailand
1994 – 1997 B.Sc. Chemistry, Prince of Songkla University, Hat Yai, Thailand

Work Experiences
2006 – 2019 Research Assistant, Chulabhorn Research Institute, Thailand
2019 – present Research Scientist, Chulabhorn Research Institute, Thailand

2001-2003 Scholarship of The institutional strengthening program, Mahidol University
2001-2004 The Postgraduate Education and Research Program in Chemistry (PERCH), Mahidol University
2004-2006 Programme on Research and Development of Synthetic Drugs, Institute of Science and Technology for Research and Development, Mahidol University, Salaya Campus, Nakornpathom, Thailand

Selected Publications

  1. Worayuthakarn, R.; Suddee, N.; Nealmongkol, P.; Ruchirawat, S.; Thasana, N. Copper-mediated C-O/C-N Bond Formation: A Facile Synthesis of 3-Amidocoumarin, 3-Amidoazacoumarin, and N-Aeroylindole Derivatives. Synlett 2022, 33, 1431–1437.
  2. Worayuthakarn, R.; Deesiri, S.; Chainok, K.; Wannarit, N.; Ruchirawat, S.; Thasana, N. Highly Regioselective Tandem Reaction of Ene-Yne-Oxazolones Induced by H-Phosphonates: Construction of Phosphinylindane Derivatives. J. Org. Chem. 2021, 86, 9360–9383.
  3. Pramthaisong, C.; Worayuthakarn R.; Pharikronburee, V.; Duangthongyou, T.; Rattanakam, R.; Ruchirawat, S.; Thasana, N. Base-Mediated Cascade Cyclization: Stereoselective Synthesis of Benzooxazocinone. Org. Lett. 2018, 20, 4015–4019.

Other Publications

  1. Tangdenpaisal, K.; Worayuthakarn, R.; Karnkla, S.; Ploypradith, P.; Intachote, P.;
    Sengsai, S.; Saimanee, B.; Ruchirawat, S.; Chittchang, M. Designing New Analogs for Streamlining the Structure of Cytotoxic Lamellarin Natural Products. Chem. Asian J. 2015, 10, 925–937.
  2. Worayuthakarn, R.; Boonya-udtayan, S; Arom-oon, E; Ruchirawat, S; Thasana, N. Total Synthesis of Unsymmetrical Benzils, Scandione and Calophione A. Eur. J. Org. Chem. 2014, 2496–2507.
  3. Worayuthakarn, R.; Nealmongkol, P.; Ruchirawat, S.; Thasana N.; Synthesis of benzoindoloquinolizines via a Cu(I)-mediated C-N bond formation. Tetrahedron 2012, 68, 2864–2875.
  4. Kanintronkul, Y; Worayuthakarn, R; Thasana, N; Winayanuwattikun, P; Pattanapanyasat, K; Surarit, R; Ruchirawat, S; Svasti, J. Overcoming multidrug resistance in human lung cancer with novel benzo[a]quinolizin-4-ones. Anticancer Res. 2011, 31, 921–928.
  5. Worayuthakarn, R; Boonya-udtayan, S; Arom-oon, E; Ploypradith, P; Ruchirawat, S; Thasana, N. Synthesis of Unsymmetrical Benzil Licoagrodione. J. Org. Chem. 2008, 73, 7432–7435.
  6. Thasana, N; Worayuthakarn, R; Kradanrat, P; Hohn, E; Young, L; Ruchirawat, S. Copper(I)-Mediated and Microwave-Assisted Caryl-Ocarboxylic Coupling: Synthesis of Benzopyranones and Isolamellarin Alkaloids. J. Org. Chem. 2007, 72, 9379–9382.
  7. Worayuthakarn, R; Thasana, N; Ruchirawat, S. Three distinct reactions of 3,4-dihydroisoquinolines with azlactones: novel synthesis of imidazoloisoquinolin-3-ones, benzo[a]quinolizin-4-ones, and benzo[d]azocin-4-ones. Org. Lett. 2006, 8, 5845–5848.


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