Dr. Pattama Singhirunnusorn

Name: Dr. Pattama Singhirunnusorn

Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute,
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +662–5538555 ext. 3135 (office), +6687–5915431 (mobile)
Fax: +662–5538572

Positions: Research Scientist, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute
E–mail: pattama@cri.or.th

Website: –

Research Interests

• Signal transduction
• Cell and Molecular Biology

Education and Degrees: 

• B.Sc. (Chemistry), Suan Dusit Rajabhat University, Bangkok, Thailand, 1994–1997
• M.Sc. (Pharmaceutical Chemistry), Mahidol University, Bangkok, Thailand, 1999–2002
• Ph.D. (Pharmaceutical Science), University of Toyama, Toyama, Japan, 2002–2005

Academic Positions

• Researcher, Department of Pharmacognosy, Faculty of pharmacy, Mahidol University, Thailand, 1998
• Postdoctoral Fellow, Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Japan, 2006–2008
• Researcher, Chemical Carcinogenesis laboratory, Chulabhorn Research Institute, 2008–present

Academic Activities

Local Activities

• Project proposal committee (2015–2016), Thesis defend committee (2016–2017), Anti–Aging and Regenerative Medicine Faculty, Dhurakij Pundit University   

Fellowships

• Postdoctoral Fellow, Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Japan, 2006–2008

International Awards & Honours

• Toyama New Industry Organization Grants, Japan, 2006–2007
• Monbukagakusho Scholarship, Japan, 2002–2005

Local Awards & Honours

• Poster award at The 10th National Cancer Conference, Bangkok, Thailand, 2009

ORCID iD:  https://orcid.org/0000–0002–8085–5417

Publications

A. Research Articles in International Journals

• Singhirunnusorn, P., Moolmuang, B., Lirdprapamongkol, K., & Ruchirawat, M. (2018). Arsenite exposure potentiates apoptosis–inducing effects of tumor necrosis factor–alpha– through reactive oxygen species. J Toxicol Sci, 43(2), 159–169. doi:10.2131/jts.43.159 

• Moolmuang, B., Singhirunnusorn, P., & Ruchirawat, M. (2016). Effects of 5–Aza–2′–Deoxycytidine, Bromodeoxyuridine, Interferons and Hydrogen Peroxide on Cellular Senescence in Cholangiocarcinoma Cells. Asian Pac J Cancer Prev, 17(3), 957–963. doi:10.7314/apjcp.2016.17.3.957

• Shin, M. S., Shinghirunnusorn, P., Sugishima, Y., Nishimura, M., Suzuki, S., Koizumi, K., . . . Sakurai, H. (2009). Cross interference with TNF–alpha–induced TAK1 activation via EGFR–mediated p38 phosphorylation of TAK1–binding protein 1. Biochim Biophys Acta, 1793(7), 1156–1164. doi:10.1016/j.bbamcr.2009.04.005 

• Nishimura, M., Shin, M. S., Singhirunnusorn, P., Suzuki, S., Kawanishi, M., Koizumi, K., . . . Sakurai, H. (2009). TAK1–mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal–regulated kinase: NF–{kappa}B–independent survival pathways in tumor necrosis factor alpha signaling. Mol Cell Biol, 29(20), 5529–5539. doi:10.1128/MCB.00375–09

• Singhirunnusorn, P., Ueno, Y., Matsuo, M., Suzuki, S., Saiki, I., & Sakurai, H. (2007). Transient suppression of ligand–mediated activation of epidermal growth factor receptor by tumor necrosis factor–alpha through the TAK1–p38 signaling pathway. J Biol Chem, 282(17), 12698–12706. doi:10.1074/jbc.M608723200

• Suzuki, S., Singhirunnusorn, P., Mori, A., Yamaoka, S., Kitajima, I., Saiki, I., & Sakurai, H. (2007). Constitutive activation of TAK1 by HTLV–1 tax–dependent overexpression of TAB2 induces activation of JNK–ATF2 but not IKK–NF–kappaB. J Biol Chem, 282(35), 25177–25181. doi:10.1074/jbc.C700065200

• Suzuki, S., Singhirunnusorn, P., Nakano, H., Doi, T., Saiki, I., & Sakurai, H. (2006). Identification of TNF–alpha–responsive NF–kappaB p65–binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2. FEBS Lett, 580(13), 3257–3262. doi:10.1016/j.febslet.2006.04.086

• Choo, M. K., Kawasaki, N., Singhirunnusorn, P., Koizumi, K., Sato, S., Akira, S., . . . Sakurai, H. (2006). Blockade of transforming growth factor–beta–activated kinase 1 activity enhances TRAIL–induced apoptosis through activation of a caspase cascade. Mol Cancer Ther, 5(12), 2970–2976. doi:10.1158/1535–7163.MCT–06–0379

• Singhirunnusorn, P., Suzuki, S., Kawasaki, N., Saiki, I., & Sakurai, H. (2005). Critical roles of threonine 187 phosphorylation in cellular stress–induced rapid and transient activation of transforming growth factor–beta–activated kinase 1 (TAK1) in a signaling complex containing TAK1–binding protein TAB1 and TAB2. J Biol Chem, 280(8), 7359–7368. doi:10.1074/jbc.M407537200

• Sakurai, H., Singhirunnusorn, P., Shimotabira, E., Chino, A., Suzuki, S., Koizumi, K., & Saiki, I. (2005). TAK1–mediated transcriptional activation of CD28–responsive element and AP–1–binding site within the IL–2 promoter in Jurkat T cells. FEBS Lett, 579(29), 6641–6646. doi:10.1016/j.febslet.2005.10.059 

• Lirdprapamongkol, K., Sakurai, H., Kawasaki, N., Choo, M. K., Saitoh, Y., Aozuka, Y., . . . Saiki, I. (2005). Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci, 25(1), 57–65. doi:10.1016/j.ejps.2005.01.015