Dr. Nisachon Khunnawutmanotham

26 Jan 2023

Name : Dr. Nisachon Khunnawutmanotham (Research Scientist I)
Office Address : Room : R310 / R303C
Laboratory of Organic Synthesis
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3026, 3024)
Email : [email protected]

Research Interests
Organic synthesis
Natural products with biological activities

1999 – 2003 Ph.D Chemistry, Kasetsart University, Bangkok, Thailand
1996 – 1998 M.Sc. Chemistry, Kasetsart University, Bangkok, Thailand
1992 – 1995 B.Sc. Chemistry, Kasetsart University, Bangkok, Thailand

Work Experiences
2004 – present Research Scientist, Chulabhorn Research Institute, Thailand

2004 Royal Golden Jubilee Scholarship
1999 Student Scholarship from Development and Promotion of Science and Technology Talents (DPST)
1999 Dr.Tab Nilanidhi Prize from Dr.Tab Nilanidhi’s foundation

Selected Publications

  1. Khunnawutmanotham, N.; Chimnoi, N.; Nangkoed, P.; Wiwattanapaisarn, W.; Techasakul, S. Facile Extraction of Three Main Indole Alkaloids from Mitragyna speciosa by Using Hot Water. ChemistrySelect 2021, 6, 10221–10225.
  2. Khunnawutmanotham, N.; Laongthipparos, C.; Saparpakorn, P.; Chimnoi, N.; Techasakul, S. Synthesis of 3-Aminocoumarin-N-Benzylpyridinium Conjugates with Nanomolar Inhibitory Activity against Acetylcholinesterase. Beilstein J. Org. Chem. 2018, 14, 2545–2552.
  3. Khunnawutmanotham, N.; Sahakitpichan, P.; Chimnoi, N.; Techasakul, S. Efficient One-Pot Synthesis of Tetrahydronaphtho[2,1-f]isoquinolines by Using Domino Pictet–Spengler/Friedel–Crafts-Type Reactions. Eur. J. Org. Chem. 2017, 2017, 6434–6440.
  4. Khunnawutmanotham, N.; Chimnoi, N.; Saparpakorn, P.; Techasakul, S. Synthesis and Anti-acetylcholinesterase Activity of Scopoletin Derivatives. Bioorg. Chem. 2016, 65, 137–145.
  5. Khunnawutmanotham, N.; Sahakitpichan, P.; Chimnoi, N.; Techasakul, S. Divergent Total Syntheses to Azafluoranthene and Dehydroaporphine Alkaloids. Eur. J. Org. Chem. 2015, 2015, 6324–6332.
  6. Khunnawutmanotham, N.; Chimnoi, N.; Thitithanyanont, A.; Saparpakorn, P.; Choowongkomon, K.; Pungpo, P.; Hannongbua, S.; Techasakul, S. Dipyridodiazepinone Derivatives; Synthesis and Anti HIV-1 Activity. Beilstein J. Org. Chem. 2009, 5.
  7. Khunnawutmanotham, N.; Chimnoi, N.; Pungpo, P.; Louisirirotchanakul, S.; Hannongbua, S.; Techasakul, S. Novel 2-Chloro-8-Arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase. Molecules 2007, 12, 218–230.

Other Publications

  1. Rodphon, W.; Laohapaisan, P.; Supantanapong, N.; Reamtong, O.; Ngiwsara, L.; Lirdprapamongkol, K.; Thongsornkleep, C.; Khunnawutmanotham, N.; Tummatorn, J.; Svasti, J.; Ruchirawat, S. Synthesis of Isocryptolepine-Triazole Adducts and Evaluation of Their Cytotoxic Activity. ChemMedChem 2021, 16, 3750–3762.
  2. Khunnawutmanotham, N.; Jumpathong, W.; Eurtivong, C.; Chimnoi, N.; Techasakul, S. Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies of 2,N10-Substituted Acridones as DNA-Intercalating Agents. J. Chem. Res. 2020, 44, 410–425.
  3. Sudto, K.; Saparpakorn, P.; Tancharoen, C.; Phromyothin, D.; Techasakul, S.; Khunnawutmanotham, N.; Vajrodaya, S.; Ge, H.-M.; Tan, R.X.; Hannongbua, S. Diptoindonesin D, a Potent Antibacterial Activity against Gram-Positive Bacteria, an Inhibitor of Penicillin-Binding Protein 2a from the Stem Bark of Shorea roxburghii G.Don. Chiang Mai J. Sci. 2019, 46, 1161–1175.
  4. Nilsu, T.; Thaisaeng, W.; Thamnarak, W.; Eurtivong, C.; Jumraksa, S.; Thorroad, S.; Khunnawutmanotham, N.; Ruchirawat, S.; Thasana, N. Three Lycopodium Alkaloids from Thai Club Mosses. Phytochemistry 2018, 156, 83–88.
  5. Chimnoi, N.; Reuk-ngam, N.; Chuysinuan, P.; Khlaychan, P.; Khunnawutmanotham, N.; Chokchaichamnankit, D.; Thamniyom, W.; Klayruang, S.; Mahidol, C.; Techasakul, S. Characterization of Essential Oil from Ocimum gratissimum Leaves: Antibacterial and Mode of Action against Selected Gastroenteritis Pathogens. Microb. Pathog2018, 118, 290–300.
  6. Reuk-ngam, N.; Chimnoi, N.; Khunnawutmanotham, N.; Techasakul, S. Antimicrobial Activity of Coronarin D and its Synergistic Potential with Antibiotics. Biomed Res. Int. 2014, Article ID 581985, 8 pages.
  7. Chimnoi, N.; Khunnawutmanotham, N.; Feungfuloy, P.; Chatrewongwan, K.; Techasakul, S. Facile Isolation and Purification of Thailandine, a Biologically Active Oxoaporphine Alkaloid, from Stephania venosa Leaves Using Ion-Pair Liquid-Liquid Extraction. Res. J. Med. Plant 2013, 7, 68-76.
  8. Khunnawutmanotham, N.; Chimnoi, N.; Champathong, W.; Lerdsirisuk, P.; Khotmor, T.; Techasakul, S. Coronarin D Conjugated to Methylene Homologs of Chlorambucil: Synthesis and Evaluation of Their Cytotoxicity. J. Chem. Res. 2012, 36, 374-378.
  9. Chokchaichamnankit, D.; Kongjinda, V.; Khunnawutmanotham, N.; Chimnoi, N.; Pisutcharoenpong, S.; Techasakul, S. Prenylated Flavonoids from the Leaves of Derris malaccensis and Their Cytotoxicity. Nat. Prod. Commun. 2011, 6, 1103–1106.
  10. Phakhodee, W.; Toyoda, M.; Chou, C.-M.; Khunnawutmanotham, N.; Isobe, M. Suzuki-Miyaura Coupling for Ggeneral Synthesis of Dehydrocoelenterazine Applicable for 6-Position Analogs Directing toward Bioluminescence Studies. Tetrahedron 2011, 67, 1150–1157.
  11. Makarasen, A.; Sirithana, W.; Mogkhuntod, S.; Khunnawutmanotham, N.; Chimnoi, N.; Techasakul, S. Cytotoxic and Antimicrobial Activities of Aporphine Alkaloids Isolated from Stephania venosa (Blume) Spreng. Planta Med. 2011, 77, 1519–1524.
  12. Achiwawanich, S.; Khunnawutmanotham, N.; Techasakul, S.; Chaichit, N.; Siripaisarnpipata, S. 1-(2-Bromobenzoyl)-6,7-(methylenedioxy) Isoquinoline. Acta Cryst. 2011, E67, o112.
  13. Chimnoi, N.; Sarasuk, C.; Khunnawutmanotham, N.; Intachote, P.; Seangsai, S.; Saimanee, B.; Pisutjaroenpong, S.; Mahidol, C.; Techasakul, S. Phytochemical Reinvestigation of Labdane-Type Diterpenes and Their Cytotoxicity from the Rhizomes of Hedychium coronarium. Phytochem. Lett. 2009, 2, 184–187.
  14. Chimnoi, N.; Pisutcharoenpong, S.; Ngiwsara, L.; Dechtrirut, D.; Chokchaichamnankit, D.; Khunnawutmanotham, N.; Mahidol, C.; Techasakul, S. Labdane Diterpenes from the Rhizome of Hedychium coronarium. Nat. Prod. Res. 2008, 22, 1255–1262.
  15. Chaosuancharoen, N.; Kongkathip, N.; Kongkathip, B. A Novel Synthetic Approach from Diosgenin to a 17α-Hydroxy Orthoester via a Regio- and Stereo-specific Rearrangement of an Epoxy Ester. Synth. Commun. 2004, 34, 961–983.


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