Dr. Lukana Ngiwsara

18 Feb 2023

Name: Dr. Lukana Ngiwsara

Office address: B701C, 7th Floor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 2553 8555 (ext. 3237-8)
E-mail: [email protected]


Research Scientist I

Research interests

Human genetic disease

Cancer biology

– B.Sc. (Biochemistry), Chulalongkorn University, Thailand
– M.S. (Biochemistry), Mahidol University, Thailand
– M.S. (Agrobiology), Hokkaido University, Japan – Ph.D. (Agrobiology), Hokkaido University, Japan


2000-2002 Royal Golden Jubilee (Chulabhorn foundation)

2007-2012 Japanese Government Scholarship (MEXT)


– Anurathapan U, Tim-Aroon T, Zhang W, Sanpote W, Wongrungsri S, Khunin N, Chutipongtanate S, Chirdkiatgumchai V, Ngiwsara L, Jaovisidha S, Khongkraparn A, Pakakasama S, Svasti J, Setchell KDR, Wattanasirichaigoon D, Hongeng S. Comprehensive and long-term outcomes of enzyme replacement therapy followed by stem cell transplantation in children with Gaucher disease type 1 and 3. Pediatr Blood Cancer. 2023 Mar;70(3):e30149. doi: 10.1002/pbc.30149. Epub 2022 Dec 23.

Ngiwsara L, Sawangareetrakul P, Wattanasirichaigoon D, Tim-Aroon T, Dejkhamron P, Champattanachai V, Ketudat-Cairns JR, Svasti J. Effects of gentamicin inducing readthrough premature stop Codons: A study of alpha-L-iduronidase nonsense variants in COS-7 Cells. Biochem Biophys Res Commun. 2022 Oct 27;636(Pt 1):147-154. doi: 10.1016/j.bbrc.2022.10.081.

– Chaiputtanapun P, Lirdprapamongkol K, Thanaussavadate B, Phongphankhum T, Thippong T, Thangsan P, Montatip P, Ngiwsara L, Svasti J, Chuawong P. Biphasic Dose-Dependent G0/G1 and G2/M Cell-Cycle Arrest by Synthetic 2,3-Arylpyridylindole Derivatives in A549 Lung Cancer Cells. ChemMedChem. 2022 Jul 19;17(14):e202200127. doi: 10.1002/cmdc.202200127.

– Gorantla JN, Maniganda S, Pengthaisong S, Ngiwsara L, Sawangareetrakul P, Chokchaisiri S, Kittakoop P, Svasti J, Ketudat Cairns JR. Chemoenzymatic and Protecting-Group-Free Synthesis of 1,4-Substituted 1,2,3-Triazole-α-d-glucosides with Potent Inhibitory Activity toward Lysosomal α-Glucosidase. ACS Omega. 2021 Sep 22;6(39):25710-25719. doi: 10.1021/acsomega.1c03928.

– Rodphon W, Laohapaisan P, Supantanapong N, Reamtong O, Ngiwsara L, Lirdprapamongkol K, Thongsornkleeb C, Khunnawutmanotham N, Tummatorn J, Svasti J, Ruchirawat S. Synthesis of Isocryptolepine-Triazole Adducts and Evaluation of Their Cytotoxic Activity. ChemMedChem. 2021 Dec 14;16(24):3750-3762. doi: 10.1002/cmdc.202100554.

– Sawangareetrakul P, Ngiwsara L, Champattanachai V, Chokchaichamnankit D, Saharat K, Ketudat Cairns JR, Srisomsap C, Khwanraj K, Dharmasaroja P, Pulkes T, Svasti J. Aberrant proteins expressed in skin fibroblasts of Parkinson’s disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes. Biomed Rep. 2021 Apr;14(4):36. doi: 10.3892/br.2021.1412.

Ngiwsara L, Vatanavicharn N, Sawangareetrakul P, Liammongkolkul S, Ratanarak P, Boonyawat B, Srisomsap C, Champattanachai V, Ketudat-Cairns J, Wasant P, Svasti J. Molecular characterization of Thai patients with phenylalanine hydroxylase deficiency and in vitro functional study of two novel PAH variants. Mol Biol Rep. 2021 Mar;48(3):2063-2070. doi: 10.1007/s11033-021-06163-w.

– Jatooratthawichot P, Talabnin C, Ngiwsara L, Rustam YH, Svasti J, Reid GE, Ketudat Cairns JR. Effect of Expression of Human Glucosylceramidase 2 Isoforms on Lipid Profiles in COS-7 Cells. Metabolites. 2020 Nov 27;10(12):488. doi: 10.3390/metabo10120488.

– Kantaputra PN, Dejkhamron P, Tongsima S, Ngamphiw C, Intachai W, Ngiwsara L, Sawangareetrakul P, Svasti J, Olsen B, Cairns JRK, Bumroongkit K. Juberg-Hayward syndrome and Roberts syndrome are allelic, caused by mutations in ESCO2. Arch Oral Biol. 2020 Nov;119:104918. doi: 10.1016/j.archoralbio.2020.104918.

– Thanaussavadate B, Ngiwsara L, Lirdprapamongkol K, Svasti J, Chuawong P. A synthetic 2,3-diarylindole induces microtubule destabilization and G2/M cell cycle arrest in lung cancer cells. Bioorg Med Chem Lett. 2020 Jan 1;30(1):126777. doi: 10.1016/j.bmcl.2019.126777.

Ngiwsara L, Wattanasirichaigoon D, Tim-Aroon T, Rojnueangnit K, Noojaroen S, Khongkraparn A, Sawangareetrakul P, Ketudat-Cairns JR, Charoenwattanasatien R, Champattanachai V, Kuptanon C, Pangkanon S, Svasti J. Clinical course, mutations and its functional characteristics of infantile-onset Pompe disease in Thailand. BMC Med Genet. 2019 Sep 11;20(1):156. doi: 10.1186/s12881-019-0878-8.

– Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Ngiwsara L, Svasti J, Koizumi K. Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-κB/VCAM-1 pathway in human lymphatic endothelial cells. Vasc Med. 2018 Jun;23(3):201-211. doi: 10.1177/1358863X18760718.

Ngiwsara L, Ketudat-Cairns JR, Sawangareetrakul P, Charoenwattanasatien R, Champattanachai V, Kuptanon C, Pangkanon S, Tim-Aroon T, Wattanasirichaigoon D, Svasti J. p.X654R IDUA variant among Thai individuals with intermediate mucopolysaccharidosis type I and its residual activity as demonstrated in COS-7 cells. Ann Hum Genet. 2018 May;82(3):150-157. doi: 10.1111/ahg.12236.

– Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Keeratichamroen S, Ngiwsara L, Paricharttanakul NM, Lirdprapamongkol K, Weeraphan C, Svasti J, Srisomsap C. Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett. 2017 Oct;14(4):4361-4371. doi: 10.3892/ol.2017.6705.

Ngiwsara L, Rojnueangnit K, Wattanasirichaigoon D, Tim-Aroon T, Sawangareetrakul P, Champattanachai V, Ketudat-Cairns JR, Svasti J. Molecular analysis of the novel <i>IDS</i> allele in a Thai family with mucopolysaccharidosis type II: The c.928C>T (p.Gln310*) transcript is sensitive to nonsense-mediated mRNA decay. Exp Ther Med. 2017 Jun;13(6):2989-2996. doi: 10.3892/etm.2017.4303.

– Rukkijakan T, Ngiwsara L, Lirdprapamongkol K, Svasti J, Phetrak N, Chuawong P. A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells. Bioorg Med Chem Lett. 2016 May 1;26(9):2119-23. doi: 10.1016/j.bmcl.2016.03.079.

– Lang W, Sirisansaneeyakul S, Martins LO, Ngiwsara L, Sakairi N, Pathom-aree W, Okuyama M, Mori H, Kimura A. Biodecolorization of a food azo dye by the deep sea Dermacoccus abyssi MT1.1(T) strain from the Mariana Trench. J Environ Manage. 2014 Jan;132:155-64. doi: 10.1016/j.jenvman.2013.11.002.

– Lang W, Sirisansaneeyakul S, Ngiwsara L, Mendes S, Martins LO, Okuyama M, Kimura A. Characterization of a new oxygen-insensitive azoreductase from Brevibacillus laterosporus TISTR1911: toward dye decolorization using a packed-bed metal affinity reactor. Bioresour Technol. 2013 Dec;150:298-306. doi: 10.1016/j.biortech.2013.09.124.

Ngiwsara L, Iwai G, Tagami T, Sato N, Nakai H, Okuyama M, Mori H, Kimura A. Amino acids in conserved region II are crucial to substrate specificity, reaction velocity, and regioselectivity in the transglucosylation of honeybee GH-13 α-glucosidases. Biosci Biotechnol Biochem. 2012;76(10):1967-74. doi: 10.1271/bbb.120473.

– Chimnoi N, Pisutjaroenpong S, Ngiwsara L, Dechtrirut D, Chokchaichamnankit D, Khunnawutmanotham N, Mahidol C, Techasakul S. Labdane diterpenes from the rhizomes of Hedychium coronarium. Nat Prod Res. 2008;22(14):1249-56. doi: 10.1080/14786410701726434.

– Keeratichamroen S, Cairns JR, Wattanasirichaigoon D, Wasant P, Ngiwsara L, Suwannarat P, Pangkanon S, Kuptanon J, Tanpaiboon P, Rujirawat T, Liammongkolkul S, Svasti J. Molecular analysis of the iduronate-2-sulfatase gene in Thai patients with Hunter syndrome. J Inherit Metab Dis. 2008 Dec;31 Suppl 2:S303-11. doi: 10.1007/s10545-008-0876-z.

– Suwannarat P, Keeratichamroen S, Wattanasirichaigoon D, Ngiwsara L, Cairns JR, Svasti J, Visudtibhan A, Pangkanon S. Molecular characterization of type 3 (neuronopathic) Gaucher disease in Thai patients. Blood Cells Mol Dis. 2007 Nov-Dec;39(3):348-52. doi: 10.1016/j.bcmd.2007.06.015.

– Srisomsap C, Subhasitanont P, Sawangareetrakul P, Chokchaichamnankit D, Ngiwsara L, Chiablaem K, Svasti J. Comparison of membrane-associated proteins in human cholangiocarcinoma and hepatocellular carcinoma cell lines. Proteomics Clin Appl. 2007 Jan;1(1):89-106. doi: 10.1002/prca.200600168.

– Wattanasirichaigoon D, Svasti J, Cairns JR, Tangnararatchakit K, Visudtibhan A, Keeratichamroen S, Ngiwsara L, Khowsathit P, Onkoksoong T, Lekskul A, Mongkolsiri D, Jariengprasert C, Thawil C, Ruencharoen S. Clinical and molecular characterization of an extended family with Fabry disease. J Med Assoc Thai.2006 Sep;89(9):1528-35. PMID: 17100396.

– Ketudat Cairns JR, Keeratichamroen S, Sukcharoen S, Champattanachai V, Ngiwsara L, Lirdprapamongkol K, Liammongkolkul S, Srisomsap C, Surarit R, Wasant P, Svasti J. The molecular basis of mucopolysaccharidosis type I in two Thai patients. Southeast Asian J Trop Med Public Health. 2005 Sep;36(5):1308-12.

– Svasti J, Srisomsap C, Subhasitanont P, Keeratichamroen S, Chokchaichamnankit D, Ngiwsara L, Chimnoi N, Pisutjaroenpong S, Techasakul S, Chen ST. Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis. Proteomics. 2005 Nov;5(17):4504-9. doi: 10.1002/pmic.200401315.

Ngiwsara L, Srisomsap C, Winichagoon P, Fucharoen S, Sae-Ngow B, Svasti J. Hb Kurosaki [alpha7(A5)Lys –>Glu (AAG –> GAG)]: an alpha2-globin gene mutation found in Thailand. Hemoglobin. 2005;29(2):155-9.

Ngiwsara L, Srisomsap C, Winichagoon P, Fucharoen S, Svasti J. Two cases of compound heterozygosity for Hb Hekinan [alpha27(B8)Glu–>Asp (alpha1)] and alpha-thalassemia in Thailand. Hemoglobin. 2004 May;28(2):145-50. doi: 10.1081/hem-120035913.

Ngiwsara L, Srisomsap C, Winichagoon P, Fucharoen S, Svasti J. Hb Kodaira II [beta146(HC3)His –> Gln] detected in Thailand. Hemoglobin. 2003 Feb;27(1):37-9. doi: 10.1081/hem-120018434. PMID: 12603092.


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