Dr. James R. Ketudat Cairns

23 Mar 2023

Name: Dr. James R. Ketudat Cairns

Office address: School of Chemistry, Institute of Science, C2-403, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhon Ratchasima 30000, Thailand

Tel: +66 44 224304

Mobile: +66 831001112
Fax: +66-44 225185
E-mail: [email protected]


Research Interests
Enzyme structure and mechanism; carbohydrate active enzymes; rice enzymes; molecular basis of genetic disease; application of enzymes, biomass breakdown and utilization

– B.Sc. (Biology) University of Puget Sound, UNITED STATES OF AMERICA
– Ph.D. (Biology), University of California, San Diego, CA, UNITED STATES OF AMERICA




  1. Choknud S, Prawisut A, Gorantla JN, Ketudat Cairns JR. (Accepted 14 February 2023) Expression, purification, characterization and glycoside production potential of rice β-D-glucan glucohydrolase I (OsExoI). Process Biochemistry 2023; 127, 145-154.
  2. Kantaputra P, Jatooratthawichot P, Adisornkanj P, Kitsadayurach P, Kaewgahya M, Olsen B, Ohazama A, Ngamphiw C, Tongsima S, Cox TC, Ketudat Cairns JR. Rare variants in LRP4 are associated with mesiodens, root maldevelopment, and oral exostoses in humans. Biology 2023; 12, 220.
  3. Fatchiyah F, Safitri A, Palis CN, Sari DRT, Suyanto E, Fajriani S, Kurnianingsih N, Nugraha Y, Sitaresmi T, Kusbiantoro B, Ketudat-Cairns JR (2023) Bioactive compound profile and their biological activities of endogenous black rice from Java and East Nusa Tenggara, CyTA – Journal of Food, 21:1, 159-170.
  4. Kantaputra P, Angkurawaranon S, Intachai W, Ngamphiw C, Olsen B, Tongsima S, Cox TC, Ketudat Cairns JR. A Founder Intronic Variant in P3H1 Likely Results in Aberrant Splicing and Protein Truncation in Patients of Karen Descent with Osteogenesis Imperfecta Type VIII. Genes 2023; 14, 322. https://doi.org/10.3390/genes14020322
  5. Wejaphikul K, Dejkhamron P, Khorana J, Watcharachan K, Intachai W, Olsen BR, Tongsima S, Ketudat Cairns JB, Ngamphiw C, Kantaputra P. Subtotal parathyroidectomy successfully controls calcium levels of patients with neonatal severe hyperparathyroidism carrying a novel CASR mutation. Hormone Research in Paediatrics (accepted 28 November 2022) https://doi.org/10.1159/000528568
  6. Kantaputra, P., Jatooratthawichot, P., Tantachamroon, O., Nanekrungsan, K., Intachai, W., Olsen, B., Tongsima, S., Ngamphiw, C., Cairns, J.R.K. Novel Dental Anomaly–associated Mutations in WNT10A Protein Binding Sites International Dental Journal 2023; 73 (1), pp. 79-86.
  7. Kantaputra, P., Jatooratthawichot, P., Kottege, N., Anthonappa, R.P., Kaewgahya, M., Tongsima, S., Ngamphiw, C., Ketudat Cairns, J.R., Predes, D., He, X. DKK1 is a strong candidate for mesiodens and taurodontism. Clinical Genetics 2023;
  8. Ngiwsara, L., Sawangareetrakul, P., Wattanasirichaigoon, D., Tim-Aroon, T., Dejkhamron, P., Champattanachai, V., Ketudat-Cairns, J.R., Svasti, J. Effects of gentamicin inducing readthrough premature stop Codons: A study of alpha-L-iduronidase nonsense variants in COS-7 Cells. Biochemical and Biophysical Research Communications 2022; 636, pp. 147-154.
  9. Luang, S., Fernández-Luengo, X., Nin-Hill, A., Streltsov, V.A., Schwerdt, J.G., Alonso-Gil, S., Ketudat Cairns, J.R., Pradeau, S., Fort, S., Maréchal, J.-D., Masgrau, L., Rovira, C., Hrmova, M. The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases. Nature Communications 2022;13 (1), 5577.
  10. Kantaputra, P., Jatooratthawichot, P., Chintakanon, K., Intachai, W., Pradermdutsadeeporn, P., Adisornkanj, P., Tongsima, S., Ngamphiw, C., Olsen, B., Tucker, A.S., Ketudat Cairns, J.R. Mutations in LRP6 highlight the role of WNT signaling in oral exostoses and dental anomalies. Archives of Oral Biology 2022; 142, art. no. 105514.
  11. Kantaputra, P.N., Guven, Y., Tripuwabhrut, K., Adisornkanj, P., Hatsadaloi, A., Kaewgahya, M., Olsen, B., Ngamphiw, C., Jatooratthawichot, P., Tongsima, S., Ketudat Cairns, J.R. Mutations in LRP5 and BMP4 are associated with mesiodens, tooth agenesis, root malformation, and oral exostoses. Clinical Genetics, 2022; 102 (4), pp. 333-338.
  12. Kantaputra, P., Guven, Y., Kalayci, T., Özer, P.K., Panyarak, W., Intachai, W., Olsen, B., Carlson, B.M., Praditsap, O., Tongsima, S., Ngamphiw, C., Jatooratthawichot, P., Tucker, A.S., Ketudat Cairns, J.R. Expanding genotypic and phenotypic spectrums of LTBP3 variants in dental anomalies and short stature syndrome. (2022) Clinical Genetics, 102 (1), pp. 66-71.
  13. Huang, M., Pengthaisong, S., Charoenwattanasatien, R., Thinkumrob, N., Jitonnom, J., Ketudat Cairns, J.R. Systematic Functional and Computational Analysis of Glucose-Binding Residues in Glycoside Hydrolase Family GH116. (2022) Catalysts, 12 (3), art. no. 343.
  14. Chueakwon, P., Jatooratthawichot, P., Talabnin, K., Ketudat Cairns, J.R., Talabnin, C. Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway. Life 2022; 12 (3), art. no. 351.
  15. Gorantla, J.N., Santhi, M., Hua, Y., Ketudat Cairns, J.R. Total synthesis of ceramides and β-O-glucosylceramides via intramolecular fatty acyl group migration. New Journal of Chemistry 2022; 46 (7), pp. 3270-3276.
  16. Nikmah, I., Kongdin, M., Hua, Y., Roytrakul, S., Fatchiyah, F., Ketudat-Cairns, J.R. Release of alcohol oxidase 1 (AOX1) from Pichia pastoris during heterologous expression of rice enzymes. (2022) Asia-Pacific Journal of Science and Technology, 27 (2), art. no. APST-27-02-12.
  17. Horikoshi, S., Saburi, W., Yu, J., Matsuura, H., Cairns, J.R.K., Yao, M., Mori, H. Substrate specificity of glycoside hydrolase family 1 β-glucosidase AtBGlu42 from Arabidopsis thaliana and its molecular mechanism. (2022) Bioscience, Biotechnology and Biochemistry, 86 (2), pp. 231-245.
  18. Shim, S.-H., Mahong, B., Lee, S.-K., Kongdin, M., Lee, C., Kim, Y.-J., Qu, G., Zhang, D., Ketudat Cairns, J.R., Jeon, J.-S. Rice β-glucosidase Os12BGlu38 is required for synthesis of intine cell wall and pollen fertility. (2022) Journal of Experimental Botany, 73 (3), pp. 784-800.
  19. Meelua, W., Wanjai, T., Thinkumrob, N., Oláh, J., Mujika, J.I., Ketudat-Cairns, J.R., Hannongbua, S., Jitonnom, J. Active site dynamics and catalytic mechanism in arabinan hydrolysis catalyzed by GH43 endo-arabinanase from QM/MM molecular dynamics simulation and potential energy surface. Journal of Biomolecular Structure and Dynamics.2022; 40 (16), pp. 7439-7449.
  20. Kantaputra, P.N., Dejkhamron, P., Intachai, W., Ngamphiw, C., Ketudat Cairns, J.R., Kawasaki, K., Ohazama, A., Olsen, B., Tongsima, S., Angkurawaranon, S. A novel P3H1 mutation is associated with osteogenesis imperfecta type VIII and dental anomalies. (2021) Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132 (6), pp. e198-e207.
  21. Gorantla, J.N., Maniganda, S., Pengthaisong, S., Ngiwsara, L., Sawangareetrakul, P., Chokchaisiri, S., Kittakoop, P., Svasti, J., Ketudat Cairns, J.R. Chemoenzymatic and Protecting-Group-Free Synthesis of 1,4-Substituted 1,2,3-Triazole-α-d-glucosides with Potent Inhibitory Activity toward Lysosomal α-Glucosidase. (2021) ACS Omega, 6 (39), pp. 25710-25719.
  22. Kantaputra, P., Chaowattanapanit, S., Kiratikanon, S., Chaiwarith, R., Choonhakarn, C., Intachai, W., Quarto, N., Tongsima, S., Ketudat Cairns, J.R., Ngamphiw, C., McGrath, J.A., Chuamanochan, M. SERPINA1, generalized pustular psoriasis, and adult-onset immunodeficiency. (2021) Journal of Dermatology, 48 (10), pp. 1597-1601.
  23. Pengthaisong, S., Hua, Y., Ketudat Cairns, J.R. Structural basis for transglycosylation in glycoside hydrolase family GH116 glycosynthases. (2021) Archives of Biochemistry and Biophysics, 706, art. no. 108924.
  24. Treekoon, J., Pewklang, T., Chansaenpak, K., Gorantla, J.N., Pengthaisong, S., Lai, R.-Y., Ketudat-Cairns, J.R., Kamkaew, A. Glucose conjugated aza-BODIPY for enhanced photodynamic cancer therapy. Organic and Biomolecular Chemistry 2021; 19 (26), pp. 5867-5875.
  25. Kongdin, M., Mahong, B., Lee, S.-K., Shim, S.-H., Jeon, J.-S., Ketudat Cairns, J.R. Action of multiple rice β-glucosidases on abscisic acid glucose ester International Journal of Molecular Sciences 2021; 22 (14), art. no. 7593.
  26. Sawangareetrakul, P., Ngiwsara, L., Champattanachai, V., Chokchaichamnankit, D., Saharat, K., Ketudat Cairns, J.R., Srisomsap, C., Khwanraj, K., Dharmasaroja, P., Pulkes, T., Svasti, J. Aberrant proteins expressed in skin fibroblasts of Parkinson’s disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes. Biomedical Reports 2021; 14 (4), art. no. 36.
  27. Ngiwsara, L., Vatanavicharn, N., Sawangareetrakul, P., Liammongkolkul, S., Ratanarak, P., Boonyawat, B., Srisomsap, C., Champattanachai, V., Ketudat-Cairns, J., Wasant, P., Svasti, J. Molecular characterization of Thai patients with phenylalanine hydroxylase deficiency and in vitro functional study of two novel PAH variants. Molecular Biology Reports 2021; 48 (3), pp. 2063-2070.
  28. Kantaputra, P.N., Dejkhamron, P., Intachai, W., Ngamphiw, C., Kawasaki, K., Ohazama, A., Krisanaprakornkit, S., Olsen, B., Tongsima, S., Ketudat Cairns, J.R. Juberg-Hayward syndrome is a cohesinopathy, caused by mutation in ESCO2. (2021) European Journal of Orthodontics, 43 (1), pp. 45-50.
  29. Tananuvat, N., Tananuvat, R., Chartapisak, W., Mahanupab, P., Hokierti, C., Srikummool, M., Kampuansai, J., Intachai, W., Olsen, B., Ketudat Cairns, J.R., Kantaputra, P. Harboyan syndrome: novel SLC4A11 mutation, clinical manifestations, and outcome of corneal transplantation. Journal of Human Genetics 2021; 66 (2), pp. 193-203.
  30. Ngivprom, U., Kluaiphanngam, S., Ji, W., Siriwibool, S., Kamkaew, A., Ketudat Cairns, J.R., Zhang, Q., Lai, R.-Y. Characterization of NucPNP and NucV involved in the early steps of nucleocidin biosynthesis in: Streptomyces calvus. RSC Advances 2021; 11 (6), pp. 3510-3515.
  31. Sari, D.R.T., Paemanee, A., Roytrakul, S., Cairns, J.R.K., Safitri, A., Fatchiyah, F. Black rice cultivar from Java Island of Indonesia revealed genomic, proteomic, and anthocyanin nutritional value. Acta Biochimica Polonica 2021; 68 (1), pp. 55-63.
  32. Baiya, S., Pengthaisong, S., Kitjaruwankul, S., Ketudat Cairns, J.R. Structural analysis of rice Os4BGlu18 monolignol ß-glucosidase. (2021) PLoS ONE, 16 (1 January), art. no. e0241325.
  33. Songsiriritthigul, C., Nualkaew, N., Ketudat-Cairns, J., Chen, C.-J. The crystal structure of benzophenone synthase from Garcinia mangostana L. pericarps reveals the basis for substrate specificity and catalysis. (2020) Acta Crystallographica Section F: Structural Biology Communications, 76, pp. 597-603.
  34. Jatooratthawichot, P., Talabnin, C., Ngiwsara, L., Rustam, Y.H., Svasti, J., Reid, G.E., Ketudat Cairns, J.R. Effect of expression of human glucosylceramidase 2 isoforms on lipid profiles in cos-7 cells. (2020) Metabolites, 10 (12), art. no. 488, pp. 1-18.
  35. Kantaputra, P.N., Intachai, W., Carlson, B., Olsen, B., Ngaohirunphat, S., Sri-Oon, J., Ketudat Cairns, J.R., Choovuthayakorn, J. Are dental anomalies associated with Tietz syndrome? (2020) European Journal of Dermatology, 30 (6), pp. 734-736.
  36. Kuntothom, T., Cairns, J.K. Expression and characterization of TbCel12A, a thermophilic endoglucanase with potential in biomass hydrolysis. (2020) Biocatalysis and Agricultural Biotechnology, 30, art. no. 101835.
  37. Kantaputra, P.N., Dejkhamron, P., Tongsima, S., Ngamphiw, C., Intachai, W., Ngiwsara, L., Sawangareetrakul, P., Svasti, J., Olsen, B., Cairns, J.R.K., Bumroongkit, K. Juberg-Hayward syndrome and Roberts syndrome are allelic, caused by mutations in ESCO2. (2020) Archives of Oral Biology, 119, art. no. 104918.
  38. Prawisut, A., Choknud, S., Ketudat Cairns, J.R. Expression of rice β-exoglucanase II (OsExoII) in Escherichia coli, purification, and characterization. (2020) Protein Expression and Purification, 175, art. no. 105708.
  39. Fatchiyah, F., Sari, D.R.T., Safitri, A., Cairns, J.R.K. Phytochemical compound and nutritional value in black rice from Java Island, Indonesia. (2020) Systematic Reviews in Pharmacy, 11 (7), pp. 414-421.
  40. Sari, D.R.T., Safitri, A., Cairns, J.R.K., Fatchiyah. Anti-apoptotic activity of anthocyanins has potential to inhibit caspase-3 signaling. (2020) Journal of Tropical Life Science, 10 (1), pp. 15-25.
  41. Nutho, B., Pengthaisong, S., Tankrathok, A., Lee, V.S., Cairns, J.R.K., Rungrotmongkol, T., Hannongbua, S. Structural basis of specific glucoimidazole and mannoimidazole binding by os3bglu7. (2020) Biomolecules, 10 (6), art. no. 907, pp. 1-19.
  42. Streltsov, V.A., Luang, S., Peisley, A., Varghese, J.N., Ketudat Cairns, J.R., Fort, S., Hijnen, M., Tvaroška, I., Ardá, A., Jiménez-Barbero, J., Alfonso-Prieto, M., Rovira, C., Mendoza, F., Tiessler-Sala, L., Sánchez-Aparicio, J.-E., Rodríguez-Guerra, J., Lluch, J.M., Maréchal, J.-D., Masgrau, L., Hrmova, M. Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site. (2019) Nature Communications, 10 (1), art. no. 2222.
  43. Ngiwsara, L., Wattanasirichaigoon, D., Tim-Aroon, T., Rojnueangnit, K., Noojaroen, S., Khongkraparn, A., Sawangareetrakul, P., Ketudat-Cairns, J.R., Charoenwattanasatien, R., Champattanachai, V., Kuptanon, C., Pangkanon, S., Svasti, J. Clinical course, mutations and its functional characteristics of infantile-onset Pompe disease in Thailand. (2019) BMC Medical Genetics, 20 (1), art. no. 156.
  44. Kantaputra, P.N., Pruksametanan, A., Phondee, N., Hutsadaloi, A., Intachai, W., Kawasaki, K., Ohazama, A., Ngamphiw, C., Tongsima, S., Ketudat Cairns, J.R., Tripuwabhrut, P. ADAMTSL1 and mandibular prognathism. (2019) Clinical Genetics, 95 (4), pp. 507-515.
  45. Kantaputra, P.N., Smith, L.J., Casal, M.L., Kuptanon, C., Chang, Y.-C., Nampoothiri, S., Paiyarom, A., Veerasakulwong, T., Trachoo, O., Ketudat Cairns, J.R., Chinadet, W., Tanpaiboon, P. Oral manifestations in patients and dogs with mucopolysaccharidosis Type VII. (2019) American Journal of Medical Genetics, Part A, 179 (3), pp. 486-493.
  46. Sari, D.R.T., Cairns, J.R.K., Safitri, A., Fatchiyah, F. Virtual prediction of the delphinidin-3-o-glucoside and peonidin-3-O-glucoside as anti-inflammatory of TNF-α signaling. (2019) Acta Informatica Medica, 27 (3), pp. 152-157.
  47. Tran, L.T., Blay, V., Luang, S., Eurtivong, C., Choknud, S., González-Diáz, H., Ketudat Cairns, J.R. Engineering faster transglycosidases and their acceptor specificity. (2019) Green Chemistry, 21 (10), pp. 2823-2836.
  48. Gorantla, J.N., Pengthaisong, S., Choknud, S., Kaewpuang, T., Manyum, T., Promarak, V., Ketudat Cairns, J.R. Gram scale production of 1-azido-β-d-glucose: Via enzyme catalysis for the synthesis of 1,2,3-triazole-glucosides. (2019) RSC Advances, 9 (11), pp. 6211-6220.
  49. Kantaputra, P.N., Chinadet, W., Intachai, W., Ngamphiw, C., Ketudat Cairns, J.R., Tongsima, S. Isolated dentinogenesis imperfecta with glass-like enamel caused by COL1A2 mutation. (2018) American Journal of Medical Genetics, Part A, 176 (12), pp. 2919-2923.
  50. Kantaputra, P.N., Kapoor, S., Verma, P., Intachai, W., Ketudat Cairns, J.R. Split hand-foot malformation and a novel WNT10B mutation. (2018) European Journal of Medical Genetics, 61 (7), pp. 372-375.
  51. Baiya, S., Mahong, B., Lee, S.-K., Jeon, J.-S., Ketudat Cairns, J.R. Demonstration of monolignol β-glucosidase activity of rice Os4BGlu14, Os4BGlu16 and Os4BGlu18 in Arabidopsis thaliana bglu45 mutant. (2018) Plant Physiology and Biochemistry, 127, pp. 223-230.
  52. Kantaputra, P.N., Hutsadaloi, A., Kaewgahya, M., Intachai, W., German, R., Koparal, M., Leethanakul, C., Tolun, A., Ketudat Cairns, J.R. WNT10B mutations associated with isolated dental anomalies. (2018) Clinical Genetics, 93 (5), pp. 992-999.
  53. Ngiwsara, L., Ketudat-Cairns, J.R., Sawangareetrakul, P., Charoenwattanasatien, R., Champattanachai, V., Kuptanon, C., Pangkanon, S., Tim-Aroon, T., Wattanasirichaigoon, D., Svasti, J. p.X654R IDUA variant among Thai individuals with intermediate mucopolysaccharidosis type I and its residual activity as demonstrated in COS-7 cells. (2018) Annals of Human Genetics, 82 (3), pp. 150-157.
  54. Jitonnom, J., Ketudat-Cairns, J.R., Hannongbua, S. QM/MM modeling of the hydrolysis and transfructosylation reactions of fructosyltransferase from Aspergillus japonicas, an enzyme that produces prebiotic fructooligosaccharide. (2018) Journal of Molecular Graphics and Modelling, 79, pp. 175-184.
  55. Ketudat Cairns, J.R., Champattanachai, V., Srisomsap, C., Paricharttanakul, N.M., Verathamjamras, C., Lirdprapamongkol, K., Svasti, J. Conference report: the 5th Asia Pacific Protein Association Conference joint meeting with the 12th International Symposium of the Protein Society of Thailand. (2017) Biophysical Reviews, 9 (6), pp. 857-860.
  56. Kantaputra, P.N., Kapoor, S., Verma, P., Kaewgahya, M., Kawasaki, K., Ohazama, A., Ketudat Cairns, J.R. Al-Awadi-Raas-Rothschild syndrome with dental anomalies and a novel WNT7A mutation. (2017) European Journal of Medical Genetics, 60 (12), pp. 695-700.
  57. Teethaisong, Y., Evans, K., Nakouti, I., Tiamyom, K., Ketudat-Cairns, J.R., Hobbs, G., Eumkeb, G. The performance of a resazurin chromogenic agar plate with a combined disc method for rapid screening of extended-spectrum-β-lactamases, AmpC β-lactamases and co-β-lactamases in Enterobacteriaceae. (2017) Microbiology and Immunology, 61 (8), pp. 297-304.
  58. Kantaputra, P.N., Bongkochwilawan, C., Lubinsky, M., Pata, S., Kaewgahya, M., Tong, H.J., Ketudat Cairns, J.R., Guven, Y., Chaisrisookumporn, N. Periodontal disease and FAM20A mutations. (2017) Journal of Human Genetics, 62 (7), pp. 679-686.
  59. Ngiwsara, L., Rojnueangnit, K., Wattanasirichaigoon, D., Tim-Aroon, T., Sawangareetrakul, P., Champattanachai, V., Ketudat-Cairns, J.R., Svasti, J. Molecular analysis of the novel IDS allele in a Thai family with mucopolysaccharidosis type II: The c.928C>T (p.Gln310*) transcript is sensitive to nonsense-mediated mRNA decay. (2017) Experimental and Therapeutic Medicine, 13 (6), pp. 2989-2996.
  60. Fatchiyah, F., Rahasta, A.H., Cairns, J.R.K. Virtual screening and prediction of binding of caprine CSN1S2 protein tryptic peptides to glucokinase. (2017) Acta Informatica Medica, 25 (4), pp. 225-231.
  61. Rimlumduan, T., Hua, Y.-L., Tanaka, T., Ketudat Cairns, J.R. Structure of a plant β-galactosidase C-terminal domain. (2016) Biochimica et Biophysica Acta – Proteins and Proteomics, 1864 (10), pp. 1411-1418.
  62. Charoenwattanasatien, R., Pengthaisong, S., Breen, I., Mutoh, R., Sansenya, S., Hua, Y., Tankrathok, A., Wu, L., Songsiriritthigul, C., Tanaka, H., Williams, S.J., Davies, G.J., Kurisu, G., Cairns, J.R.K. Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2). (2016) ACS Chemical Biology, 11 (7), pp. 1891-1900.
  63. Kantaputra, P.N., Kaewgahya, M., Hatsadaloi, A., Vogel, P., Kawasaki, K., Ohazama, A., Ketudat Cairns, J.R. GREMLIN 2 mutations and dental anomalies. (2015) Journal of Dental Research, 94 (12), pp. 1646-1652.
  64. Sawangareetrakul, P., Ketudat Cairns, J.R., Vatanavicharn, N., Liammongkolkul, S., Wasant, P., Svasti, J., Champattanachai, V. Analysis of Novel Mutations and Methylmalonyl-CoA Mutase Levels in Thai Patients with Isolated Methylmalonic Acidemia. (2015) Biochemical Genetics, 53 (11-12), pp. 310-318.
  65. Ketudat Cairns, J.R., Mahong, B., Baiya, S., Jeon, J.-S. β-Glucosidases: Multitasking, moonlighting or simply misunderstood? (2015) Plant Science, 241, pp. 246-259.
  66. Komvongsa, J., Mahong, B., Phasai, K., Hua, Y., Jeon, J.-S., Ketudat Cairns, J.R. Identification of Fatty Acid Glucose Esters as Os9BGlu31 Transglucosidase Substrates in Rice Flag Leaves. (2015) Journal of Agricultural and Food Chemistry, 63 (44), pp. 9764-9769.
  67. Tankrathok, A., Iglesias-Fernández, J., Williams, R.J., Pengthaisong, S., Baiya, S., Hakki, Z., Robinson, R.C., Hrmova, M., Rovira, C., Williams, S.J., Ketudat Cairns, J.R. A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides. (2015) ACS Catalysis, 5 (10), pp. 6041-6051.
  68. Hua, Y., Ekkhara, W., Sansenya, S., Srisomsap, C., Roytrakul, S., Saburi, W., Takeda, R., Matsuura, H., Mori, H., Ketudat Cairns, J.R. Identification of rice Os4BGlu13 as a β-glucosidase which hydrolyzes gibberellin A4 1-O-β-d-glucosyl ester, in addition to tuberonic acid glucoside and salicylic acid derivative glucosides. (2015) Archives of Biochemistry and Biophysics, 583, art. no. 7033, pp. 36-46.
  69. Komvongsa, J., Luang, S., Marques, J.V., Phasai, K., Davin, L.B., Lewis, N.G., Ketudat Cairns, J.R. Active site cleft mutants of Os9BGlu31 transglucosidase modify acceptor substrate specificity and allow production of multiple kaempferol glycosides. (2015) Biochimica et Biophysica Acta – General Subjects, 1850 (7), pp. 1405-1414.
  70. Sansenya, S., Mutoh, R., Charoenwattanasatien, R., Kurisu, G., Ketudat Cairns, J.R. Expression and crystallization of a bacterial glycoside hydrolase family 116 β-glucosidase from Thermoanaerobacterium xylanolyticum. (2015) Acta Crystallographica Section F:Structural Biology Communications, 71, pp. 41-44.
  71. Pengthaisong, S., Ketudat Cairns, J.R. Effects of active site cleft residues on oligosaccharide binding, hydrolysis, and glycosynthase activities of rice BGlu1 and its mutants. (2014) Protein Science, 23 (12), pp. 1738-1752.
  72. Tananuvat, N., Charoenkwan, P., Ohazama, A., Ketuda Cairns, J.R., Kaewgahya, M., Kantaputra, P.N. Root dentin anomaly and a PLG mutation. (2014) European Journal of Medical Genetics, 57 (11-12), pp. 630-635.
  73. Rouyi, C., Baiya, S., Lee, S.-K., Mahong, B., Jeon, J.-S., Ketudat- Cairns, J.R., Ketudat-Cairns, M. Recombinant expression and characterization of the cytoplasmic rice β-glucosidase Os1BGlu4. (2014) PLoS ONE, 9 (5), art. no. e96712.
  74. Baiya, S., Hua, Y., Ekkhara, W., Ketudat Cairns, J.R. Expression and enzymatic properties of rice (Oryza sativa) monolignol β-glucosidases (2014) Plant Science, 227, pp. 101-109.
  75. Tankrathok, A., Iglesias-Fernández, J., Luang, S., Robinson, R.C., Kimura, A., Rovira, C., Hrmova, M., Ketudat Cairns, J.R. Structural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 β-d-mannosidase. (2013) Acta Crystallographica Section D: Biological Crystallography, 69 (10), pp. 2124-2135.
  76. Himeno, N., Saburi, W., Wakuta, S., Takeda, R., Matsuura, H., Nabeta, K., Sansenya, S., Ketudat Cairns, J.R., Mori, H., Imai, R., Matsui, H. Identification of rice β-glucosidase with high hydrolytic activity towards salicylic acid β-d-glucoside. (2013) Bioscience, Biotechnology and Biochemistry, 77 (5), pp. 934-939.
  77. Luang, S., Cho, J.-I., Mahong, B., Opassiri, R., Akiyama, T., Phasai, K., Komvongsa, J., Sasaki, N., Hua, Y.-L., Matsuba, Y., Ozeki, Y., Jeon, J.-S., Ketudat Cairns, J.R. Rice Os9BGlu31 is a transglucosidase with the capacity to equilibrate phenylpropanoid, flavonoid, and phytohormone glycoconjugates. (2013) Journal of Biological Chemistry, 288 (14), pp. 10111-10123.
  78. Wang, J., Pengthaisong, S., Cairns, J.R.K., Liu, Y. X-ray crystallography and QM/MM investigation on the oligosaccharide synthesis mechanism of rice BGlu1 glycosynthases. (2013) Biochimica et Biophysica Acta – Proteins and Proteomics, 1834 (2), pp. 536-545.
  79. Hua, Y., Sansenya, S., Saetang, C., Wakuta, S., Cairns, J.R.K. Enzymatic and structural characterization of hydrolysis of gibberellin A4 glucosyl ester by a rice β-D-glucosidase. (2013) Archives of Biochemistry and Biophysics, 537 (1), pp. 39-48.
  80. Charoenwattanasatien, R., Cairns, J.R.K., Keeratichamroen, S., Sawangareetrakul, P., Tanpaiboon, P., Wattanasirichaigoon, D., Pangkanon, S., Svasti, J., Champattanachai, V. Decreasing activity and altered protein processing of human iduronate-2-sulfatase mutations demonstrated by expression in COS7 cells. (2012) Biochemical Genetics, 50 (11-12), pp. 990-997.
  81. Vatanavicharn, N., Champattanachai, V., Liammongkolkul, S., Sawangareetrakul, P., Keeratichamroen, S., Ketudat Cairns, J.R., Srisomsap, C., Sathienkijkanchai, A., Shotelersuk, V., Kamolsilp, M., Wattanasirichaigoon, D., Svasti, J., Wasant, P. Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia. (2012) Molecular Genetics and Metabolism, 106 (4), pp. 424-429.
  82. Ketudat Cairns JR, Pengthaisong S, Luang S, Sansenya A, Tankrathok A, Svasti J. Protein carbohydrate interactions leading to hydrolysis and transglycosylation in plant glycoside hydrolase family 1 enzymes. Journal of Applied Glycoscience 2012; 59, 51-62.
  83. Pengthaisong, S., Chen, C.-F., Withers, S.G., Kuaprasert, B., Ketudat Cairns, J.R. Rice BGlu1 glycosynthase and wild type transglycosylation activities distinguished by cyclophellitol inhibition. (2012) Carbohydrate Research, 352, pp. 51-59.
  84. Sansenya, S., Maneesan, J., Ketudat Cairns, J.R. Exchanging a single amino acid residue generates or weakens a +2 cellooligosaccharide binding subsite in rice β-glucosidases. (2012) Carbohydrate Research, 351, pp. 130-133.
  85. Pengthaisong, S., Withers, S.G., Kuaprasert, B., Svasti, J., Ketudat Cairns, J.R. The role of the oligosaccharide binding cleft of rice BGlu1 in hydrolysis of cellooligosaccharides and in their synthesis by rice BGlu1 glycosynthase. (2012) Protein Science, 21 (3), pp. 362-372.
  86. Sansenya, S., Opassiri, R., Kuaprasert, B., Chen, C.-J., Ketudat Cairns, J.R. The crystal structure of rice (Oryza sativa) Os4BGlu12, an oligosaccharide and tuberonic acid glucoside-hydrolyzing β-glucosidase with significant thioglucohydrolase activity. (2011) Archives of Biochemistry and Biophysics, 510 (1), pp. 62-72.
  87. Negi, D.S., Kumar, A., Sharma, R.K., Shukla, N., Negi, N., Tamta, M.L., Bansal, Y., Prasert, P.-g., Cairns, J.R.K. Structure confirmation of rare conjugate glycosides from Glycosmis arborea (Roxb.) with the action of β-glucosidases. (2011) Research Journal of Phytochemistry, 5 (1), pp. 32-40.
  88. Chuenchor, W., Pengthaisong, S., Robinson, R.C., Yuvaniyama, J., Svasti, J., Cairns, J.R.K. The structural basis of oligosaccharide binding by rice BGlu1 beta-glucosidase. (2011) Journal of Structural Biology, 173 (1), pp. 169-179.
  89. Kuntothom, T., Raab, M., Tvaroška, I., Fort, S., Pengthaisong, S., Cañada, J., Calle, L., Jiménez-Barbero, J., Ketudat Cairns, J.R., Hrmova, M. Binding of β-d-glucosides and β-d-mannosides by rice and barley β-d-glycosidases with distinct substrate specificities. (2010) Biochemistry, 49 (40), pp. 8779-8793.
  90. Cairns, J.R.K., Esen, A. β-Glucosidases. (2010) Cellular and Molecular Life Sciences, 67 (20), pp. 3389-3405.
  91. Opassiri, R., Maneesan, J., Akiyama, T., Pomthong, B., Jin, S., Kimura, A., Cairns, J.R.K. Rice Os4BGlu12 is a wound-induced β-glucosidase that hydrolyzes cell wall-β-glucan-derived oligosaccharides and glycosides. (2010) Plant Science, 179 (3), pp. 273-280.
  92. Luang, S., Ketudat Cairns, J.R., Streltsov, V.A., Hrmova, M. Crystallisation of wild-type and variant forms of a recombinant plant enzyme β-D-glucan glucohydrolase from barley (Hordeum vulgare L.) and preliminary X-ray analysis. (2010) International Journal of Molecular Sciences, 11 (7), pp. 2759-2769.
  93. Sansenya, S., Ketudat Cairns, J.R., Opassiri, R. Expression, purification, crystallization and preliminary X-ray analysis of rice (Oryza sativa) Os4BGlu12 β-glucosidase. (2010) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (3), pp. 320-323.
  94. Luang, S., Hrmova, M., Ketudat Cairns, J.R. High-level expression of barley b-D-glucan exohydrolase HvExoI from a codon-optimized cDNA in Pichia pastoris. (2010) Protein Expression and Purification, 73 (1), pp. 90-98.
  95. Kaomek, M., Ketudat-Cairns, J.R. Expression of Leucaena leucocephala de wit chitinase in transgenic koshihikari rice. (2009) World Academy of Science, Engineering and Technology, 59, pp. 272-277.
  96. Kuntothom, T., Luang, S., Harvey, A.J., Fincher, G.B., Opassiri, R., Hrmova, M., Ketudat Cairns, J.R. Rice family GH1 glycoside hydrolases with β-d-glucosidase and β-d-mannosidase activities. (2009) Archives of Biochemistry and Biophysics, 491 (1-2), pp. 85-95.
  97. Akiyama, T., Jin, S., Yoshida, M., Hoshino, T., Opassiri, R., Ketudat Cairns, J.R. Expression of an endo-(1,3;1,4)-β-glucanase in response to wounding, methyl jasmonate, abscisic acid and ethephon in rice seedlings. (2009) Journal of Plant Physiology, 166 (16), pp. 1814-1825.
  98. Seshadri, S., Akiyama, T., Opassiri, R., Kuaprasert, B., Cairns, J.K. Structural and enzymatic characterization of Os3BGlu6, a rice beta;-glucosidase hydrolyzing hydrophobic glycosides and (1→3)- and (1→2)-linked disaccharides. (2009) Plant Physiology, 151 (1), pp. 47-58.
  99. Tanthanuch, W., Chantarangsee, M., Maneesan, J., Ketudat-Cairns, J. Genomic and expression analysis of glycosyl hydrolase family 35 genes from rice (Oryza sativa). (2008) BMC Plant Biology, 8, art. no. 84.
  100. Chuenchor, W., Pengthaisong, S., Robinson, R.C., Yuvaniyama, J., Oonanant, W., Bevan, D.R., Esen, A., Chen, C.-J., Opassiri, R., Svasti, J., Cairns, J.R.K. Structural Insights into Rice BGlu1 β-Glucosidase Oligosaccharide Hydrolysis and Transglycosylation. (2008) Journal of Molecular Biology, 377 (4), pp. 1200-1215.
  101. Keeratichamroen, S., Cairns, J.R.K., Wattanasirichaigoon, D., Wasant, P., Ngiwsara, L., Suwannarat, P., Pangkanon, S., Kuptanon, J., Tanpaiboon, P., Rujirawat, T., Liammongkolkul, S., Svasti, J. Molecular analysis of the iduronate-2-sulfatase gene in Thai patients with Hunter syndrome. (2008) Journal of Inherited Metabolic Disease, 31 (SUPPL. 2), pp. S303-S311.
  102. Chuankhayan, P., Rimlumduan, T., Tantanuch, W., Mothong, N., Kongsaeree, P.T., Metheenukul, P., Svasti, J., Jensen, O.N., Cairns, J.R.K. Functional and structural differences between isoflavonoid β-glycosidases from Dalbergia (2007) Archives of Biochemistry and Biophysics, 468 (2), pp. 205-216.
  103. Opassiri, R., Pomthong, B., Akiyama, T., Nakphaichit, M., Onkoksoong, T., Ketudat Cairns, M., Ketudat Cairns, J.R. A stress-induced rice (Oryza sativa) β-glucosidase represents a new subfamily of glycosyl hydrolase family 5 containing a fascin-like domain. (2007) Biochemical Journal, 408 (2), pp. 241-249.
  104. Suwannarat, P., Keeratichamroen, S., Wattanasirichaigoon, D., Ngiwsara, L., Cairns, J.R.K., Svasti, J., Visudtibhan, A., Pangkanon, S. Molecular characterization of type 3 (neuronopathic) Gaucher disease in Thai patients. (2007) Blood Cells, Molecules, and Diseases, 39 (3), pp. 348-352.
  105. Chantarangsee, M., Tanthanuch, W., Fujimura, T., Fry, S.C., Ketudat Cairns, J. Molecular characterization of β-galactosidases from germinating rice (Oryza sativa). (2007) Plant Science, 173 (2), pp. 118-134.
  106. Hommalai, G., Withers, S.G., Chuenchor, W., Cairns, J.R.K., Svasti, J. Enzymatic synthesis of cello-oligosaccharides by rice BGlu1 β-glucosidase glycosynthase mutants. (2007) Glycobiology, 17 (7), pp. 744-753.
  107. Keeratichamroen, S., Cairns, J.R.K., Sawangareetrakul, P., Liammongkolkul, S., Champattanachai, V., Srisomsap, C., Kamolsilp, M., Wasant, P., Svasti, J. Novel mutations found in two genes of Thai patients with isolated methylmalonic acidemia. (2007) Biochemical Genetics, 45 (5-6), pp. 421-430.
  108. Chuankhayan, P., Rimlumduan, T., Svasti, J., Ketudat Cairns, J.R. Hydrolysis of soybean isoflavonoid glycosides by Dalbergia β-glucosidases. (2007) Journal of Agricultural and Food Chemistry, 55 (6), pp. 2407-2412.
  109. Opassiri, R., Pomthong, B., Onkoksoong, T., Akiyama, T., Esen, A., Ketudat Cairns, J.R. Analysis of rice glycosyl hydrolase family 1 and expression of Os4bglu12 β-glucosidase. (2006) BMC Plant Biology, 6, art. no. 33.
  110. Wattanasirichaigoon, D., Svasti, J., Ketudat Cairns, J.R., Tangnararatchakit, K., Visudtibhan, A., Keeratichamroen, S., Ngiwsara, L., Khowsathit, P., Onkoksoong, T., Lekskul, A., Mongkolsiri, D., Jariengprasert, C., Thawil, C., Ruencharoen, S. Clinical and molecular characterization of an extended family with Fabry disease. (2006) Journal of the Medical Association of Thailand, 89 (9), pp. 1528-1535.
  111. Chuenchor, W., Opassiri, R., Pengthaisong, S., Yuvaniyama, J., Ketudat Cairns, J.R., Svasti, J. Purification, crystallization and preliminary X-ray analysis of rice BGlu1 β-glucosidase with and without 2-deoxy-2-fluoro-β-D-glucoside. (2006) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62 (8), pp. 798-801.
  112. Toonkool, P., Metheenukul, P., Sujiwattanarat, P., Paiboon, P., Tongtubtim, N., Ketudat-Cairns, M., Ketudat-Cairns, J., Svasti, J. Expression and purification of dalcochinase, a β-glucosidase from Dalbergia cochinchinensis Pierre, in yeast and bacterial hosts. (2006) Protein Expression and Purification, 48 (2), pp. 195-204.
  113. Chuankhayan, P., Hua, Y., Svasti, J., Sakdarat, S., Sullivan, P.A., Ketudat Cairns, J.R. Purification of an isoflavonoid 7-O-β-apiosyl-glucoside β-glycosidase and its substrates from Dalbergia nigrescens (2005) Phytochemistry, 66 (16), pp. 1880-1889.
  114. Ketudat Cairns, J.R., Keeratichamroen, S., Sukcharoen, S., Champattanachai, V., Ngiwsara, L., Lirdprapamongkol, K., Liammongkolkul, S., Srisomsap, C., Surarit, R., Wasant, P., Svasti, J. The molecular basis of mucopolysaccharidosis type I in two Thai patients. (2005) Southeast Asian Journal of Tropical Medicine and Public Health, 36 (5), pp. 1308-1312.
  115. Opassiri, R., Hua, Y., Wara-Aswapati, O., Akiyama, T., Svasti, J., Esen, A., Ketudat Cairns, J.R. β-Glucosidase, exo-β-glucanase and pyridoxine transglucosylase activities of rice BGlu1. (2004) Biochemical Journal, 379 (1), pp. 125-131.
  116. Opassiri, R., Ketudat Cairns, J.R., Akiyama, T., Wara-Aswapati, O., Svasti, J., Esen, A. Characterization of a rice β-glucosidase highly expressed in flower and germinating shoot. (2003) Plant Science, 165 (3), pp. 627-638.
  117. Champattanachai, V., Cairns, J.R.K., Shotelersuk, V., Keeratichamroen, S., Sawangareetrakul, P., Srisomsap, C., Kaewpaluek, V., Svasti, J. Novel mutations in a Thai patient with methylmalonic acidemia. (2003) Molecular Genetics and Metabolism, 79 (4), pp. 300-302.
  118. Kaomek, M., Mizuno, K., Fujimura, T., Sriyotha, P., Cairns, J.R.K. Cloning, expression, and characterization of an antifungal chitinase from Leucaena leucocephala de Wit. (2003) Bioscience, Biotechnology and Biochemistry, 67 (4), pp. 667-676.
  119. Svasti, S., Yodsowon, B., Sriphanich, R., Winichagoon, P., Boonkhan, P., Suwanban, T., Sawangareetrakul, P., Srisomsap, C., Ketudat-Cairns, J.R., Svasti, J., Fucharoen, S. Association of Hb hope [β136(H14)Gly → Asp] and Hb H disease. (2001) Hemoglobin, 25 (4), pp. 429-435.
  120. Ketudat Cairns, J.R., Champattanachai, V., Srisomsap, C., Wittman-Liebold, B., Thiede, B., Svasti, J. Sequence and expression of Thai rosewood β-glucosidase/β-fucosidase, a family 1 glycosyl hydrolase glycoprotein. (2000) Journal of Biochemistry, 128 (6), pp. 999-1008.
  121. Cairns, J.R., Price, P.A. Direct demonstration that the vitamin k‐dependent bone gla protein is incompletely γ‐carboxylated in humans. (1994) Journal of Bone and Mineral Research, 9 (12), pp. 1989-1997.
  122. Cairns, J.R., Williamson, M.K., Price, P.A. Direct identification of γ-carboxyglutamic acid in the sequencing of vitamin K-dependent proteins. (1991) Analytical Biochemistry, 199 (1), pp. 93-97.

International Proceeding Volumes

  1. Sari, D.R.T., Safitri, A., Cairns, J.R.K., Fatchiyah, F. Virtual screening of black rice anthocyanins as antiobesity through inhibiting TLR4 and JNK pathway. (2020) Journal of Physics: Conference Series, 1665 (1), art. no. 012024.
  2. Sari, D.R.T., Safitri, A., Cairns, J.R.K., Fatchiyah, F. Protein profiling of coloring rice (Oryza sativa) using SDS-PAGE and experion TM 260 analysis. (2019) Journal of Physics: Conference Series, 1146 (1), art. no. 012038.
  3. Svasti J, Srisomsap C, Surarit R, Techasakul S, and Ketudat-Cairns JR. (1998) Characterization of a novel rotenoid- β-glucosidase and its natural substrate from Thai rosewood. Journal of Pure and Applied Chemistry 70 (11).
  4. Svasti, J., Srisomsap, C., Surarit, R., Ketudat-Cairns, J., Techasakul, S. and Toonkool, P. (2004) Structure and properties of Thai plant β-glucosidases. In “Protein Structure-Function Relationship”. (A. Abbasi and S.A. Ali, eds.), BCC&T, University of Karachi, Karachi, pp 221-240.

Thai Journal Papers

  1. Baiya S, Pengthaisong S, Ketudat Cairn, JR. Crystallization and X-ray diffraction analysis of rice Os4BGlu18 (translated from: “การตกผลึกและการวิเคราะห์การเลี้ยวเบนรังสีเอ็กซ์ของเอนไซม์ Os4BGlu18 จากข้าว”) Journal of Applied Science 2017; 16(2), 37-46.
  2. Liammongkolkul S, Kuptanon C, Wasant P, Vatanavicharn N, Sawangareetrakul P, Keeraticharoen S, Ketudat Cairns JR, Srisomsap C, Svasti J. Novel mutation of methylmalonyl-CoA mutase gene in a Thai infant with methylmalonic academia (mut0). Siriraj Medical Journal 2009; 61, 215-217.
  3. Ketudat Cairns JR, Chantarangsee M, Chaiwangrad S, Phawong J. 1999. Primary structure-based screening for glycosyl hydrolases in Thai plants. Thai Journal of Biotechnology 1, 20-30.


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