Purine anabolism creates therapeutic vulnerability in hepatocellular carcinoma via m6A-mediated epitranscriptomic regulation

Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B. Techapiesancharoenkij, N., Fiala, J. L. A., Navasumrit, P., Croy, R. G., Wogan, G. N., Groopman, J. D., Essigmann, J. M. (2015). Toxicology and Applied Pharmacology, 282(1), 52-60.

Disadee, W., Mahidol, C., Sahakitpichan, P., Sitthimonchai, S., Ruchirawat, S., & Kanchanapoom, T. (2011). Flavonol 3-O-robinobiosides and 3-O-(2″-O-α-rhamnopyranosyl)-robinobiosides from Sesuvium portulacastrum. Tetrahedron, 67(23), 4221-4226. https://doi.org/10.1016/j.tet.2011.04.041