ANIMAL RESEARCH SUPPORT

Name: Miss Phannee Sawangareetrakul Office address: Laboratory of Biochemistry 7th Floor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 (ext. 3238) E-mail: [email protected] Research Scientist I Research Interests Protein and enzyme, Cancer biomarker, Human genetic disease Education – B.Sc. (Medical Technology), Mahidol University, Bangkok, THAILAND – M.Sc. (Biochemistry), Mahidol University, Bangkok, THAILAND Publications 1. Ngiwsara L, Sawangareetrakul P, Wattanasirichaigoon D, Tim-Aroon T, Dejkhamron P, Champattanachai V, Ketudat-Cairns JR, Svasti J. Effects of gentamicin inducing readthrough premature stop Codons: A study of alpha-L-iduronidase nonsense variants in COS-7 Cells. Biochem Biophys Res Commun. 2022 Oct 27;636(Pt 1):147-154. doi: 10.1016/j.bbrc.2022.10.081. 2. Gorantla JN, Maniganda S, Pengthaisong S, Ngiwsara L, Sawangareetrakul P, Chokchaisiri S, Kittakoop P, Svasti J, Ketudat Cairns JR. Chemoenzymatic and Protecting-Group-Free Synthesis of 1,4-Substituted 1,2,3-Triazole-α-d-glucosides with Potent Inhibitory Activity toward Lysosomal α-Glucosidase. ACS Omega. 2021 Sep 22;6(39):25710-25719. doi: 10.1021/acsomega.1c03928. 3. Sawangareetrakul P, Ngiwsara L, Champattanachai V, Chokchaichamnankit D, Saharat K, Ketudat Cairns JR, Srisomsap C, Khwanraj K, Dharmasaroja P, Pulkes T, Svasti J. Aberrant proteins expressed in skin fibroblasts of Parkinson’s disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes. Biomed Rep. 2021 Apr;14(4):36. doi: 10.3892/br.2021.1412. Epub 2021 Feb 17. 4. Ngiwsara L, Vatanavicharn N, Sawangareetrakul P, Liammongkolkul S, Ratanarak P, Boonyawat B, Srisomsap C, Champattanachai V, Ketudat-Cairns J,...

Arsenic is an environmental pollutant that is classified as a human carcinogen by the International Agency for Research on Cancer (IARC). It is found naturally in the environment and is also used as a therapeutic agent in pigs and chickens, as well as a pesticide. In Thailand, arsenic contamination in the environment is mainly because of tin mining, leading to contamination of food and drinking water. In animal experiments, arsenic has been shown to cross the placenta to the developing embryo and lead to cancer later in life (i.e., adulthood). The Chulabhorn Research Institute has conducted research on the impacts of exposure to arsenic in pregnant mothers on gene expression in infants. Tissue samples were collected from mothers and newborns from Ronpibul district, Nakhon Sri Thammarat province, an area known to be contaminated with arsenic. Results showed that newborns from mothers in the study area had elevated levels of arsenic in their hair and nails, compared to newborns from a control site. This was also the first published study to show differential expression of 11 genes that were identified as promising markers for arsenic exposure. These genes are involved in apoptosis, cell signaling, inflammation and stress responses. Additionally, it was found that levels of DNA methylation in the promoter region of the p53 gene were associated with levels of arsenic...