CRI Office Hour : Monday - Friday, 09.00 - 17.00

+66 2553 8555

+66 2553 8527


Action of environmental contaminants on human health

      Exposure to environmental contaminants, including pesticides and xenobiotics, is a risk factor for the development of diseases, such as cancer and neurodegenerative disorders. As pesticide use increases in Thailand, risk of exposure increases, even though new generation pesticides are supposedly safer, because farmers and/or general public are not trained on proper handling. We have used proteomics to elucidate the modes of action of pesticides and their effects, using human cancer cell lines as model systems. Exposure of high concentrations of atrazine, a triazine herbicide, on hepatocellular carcinoma cells implicated its possible involvement in causing cardiovascular diseases. On the other hand, fipronil, a broad spectrum phenylpyrazole insecticide, affected neuronal cells by altering the expression of proteins involved in protein biosynthesis, mitochondrial function, and glucose metabolism. Proteomic studies in plants in relation to pesticides are also interesting due to their importance in agriculture sector, and chlorpyrifos, an organophosphate insecticide, showed effects on proteins involved in growth and photosynthetic activity in the leaves of Chinese kale.  Moreover, the cellular and molecular effects of xenobiotics that persist in the environment, such as perfluorinated compounds, are also of interest.

Report broken file
File Broken


We use cookies to improve performance. and good experience using your website. You can study details at Cookies policy and can manage your own privacy by clicking on Settings

Privacy Preferences

You can choose your cookie settings by turning them on/off. Cookies of each category are available on request, except essential cookies.

Allow All
Manage Consent Preferences
  • Necessary
    Always Active

    Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.

  • Analytics

    Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.