Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants

20 Sep 2023
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Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants

Songvut P, Rangkadilok N, Pholphana N, Suriyo T, Duangchit P, Puranajoti P, Akanimanee J, Satayavivad J

Front Pharmacol. 2023;14:1230401.

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Thongararm, P.; Fedeles, B. I.; Khumsubdee, S.; Armijo, A. L.; Kim, L.; Thiantanawat, A.; Promvijit, J.; Navasumrit, P.; Ruchirawat, M.; Croy, R. G.; Essigmann, J. M. Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem. Res. Toxicol. 2020, 33, 625–633.
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Thongararm, P.; Fedeles, B. I.; Khumsubdee, S.; Armijo, A. L.; Kim, L.; Thiantanawat, A.; Promvijit, J.; Navasumrit, P.; Ruchirawat, M.; Croy, R. G.; Essigmann, J. M. Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem. Res. Toxicol. 2020, 33, 625–633.

Thongararm,P.; Fedeles,B. I.; Khumsubdee,S.; Armijo,A. L.; Kim, L.;Thiantanawat,A.; Promvijit,J.; Navasumrit,P.; Ruchirawat,M.; Croy,R. G.; Essigmann, J. M. Modulation ofN-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from thegptDelta Mouse by an Inhibitor of theO6-Methylguanine Methyltransferase, MGMT. Chem. Res. Toxicol.2020, 33, 625–633.
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